Evidence map›Paper›PMID 19209228›Full record

ArticlePloS one2009

Improved disorder prediction by combination of orthogonal approaches.

Avner Schlessinger, Marco Punta, Guy Yachdav, Laszlo Kajan, Burkhard Rost

Abstract read
In one paragraph

Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Predicting Protein Conformational Disorder and Disordered Binding Sites.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  9. Decoding the effects of synonymous variants.Nucleic acids research · 2021
    Article
  10. InInternational journal of molecular sciences · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Homology modeling in the time of collective and artificial intelligence.Computational and structural biotechnology journal · 2020
    Review
  17. Article
  18. Deep learning methods in protein structure prediction.Computational and structural biotechnology journal · 2020
    Review
  19. DISOselect: Disorder predictor selection at the protein level.Protein science : a publication of the Protein Society · 2020
    Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Avner SchlessingerCUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America. as2067@columbia.edu
Marco Punta
Guy Yachdav
Laszlo Kajan
Burkhard Rost

Funding

Predictions of structure/function by PredictProteinR01LM007329 · NLM · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PE'ER, ITSHACK G · 2003 to 2010
$2.6M
NLM NIH HHS R01 LM007329NLM NIH HHS R01-LM07329
6 · The paper itself

Abstract

unlabelledDisordered proteins are highly abundant in regulatory processes such as transcription and cell-signaling. Different methods have been developed to predict protein disorder often focusing on different types of disordered regions. Here, we present MD, a novel META-Disorder prediction method that molds various sources of information predominantly obtained from orthogonal prediction methods, to significantly improve in performance over its constituents. In sustained cross-validation, MD not only outperforms its origins, but it also compares favorably to other state-of-the-art prediction methods in a variety of tests that we applied. AVAILABILITY: http://www.rostlab.org/services/md/

Indexed as

Computational BiologyDatabases, ProteinModels, MolecularProteinsReproducibility of ResultsProteins

Identifiers

PMID19209228
PMCPMC2635965

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.