ArticleAnti-cancer drugs2009
Selective cytotoxic activity of the marine-derived batzelline compounds against pancreatic cancer cell lines.
Article in Anti-cancer drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Review
- Marine-Inspired Drugs and Biomaterials in the Perspective of Pancreatic Cancer Therapies.Marine drugs · 2022Review
- Review
- In Silico Pharmacokinetic Profiling of the Identified Bioactive Metabolites ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential.International journal of molecular sciences · 2022Review
- Development of Marine-Derived Compounds for Cancer Therapy.Marine drugs · 2021Review
- Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review.Biomolecules · 2021Review
- Retracted Article: The synthesis and biological activity of marine alkaloid derivatives and analogues.RSC advances · 2020Article
- Marine natural products in the discovery and development of potential pancreatic cancer therapeutics.Advances in cancer research · 2019Review
- The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells.Tetrahedron · 2018Article
- Review
- Marine Sponge Natural Products with Anticancer Potential: An Updated Review.Marine drugs · 2017Review
- Another Look at Pyrroloiminoquinone Alkaloids-Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues.Marine drugs · 2017Article
- Inhibition of IL-8 secretion on BxPC-3 and MIA PaCa-2 cells and induction of cytotoxicity in pancreatic cancer cells with marine natural products.Anti-cancer drugs · 2017Article
- Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity.International journal of cancer · 2016Article
- The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells.Marine drugs · 2013Article
- Spongiatriol inhibits nuclear factor kappa B activation and induces apoptosis in pancreatic cancer cells.Marine drugs · 2013Article
- Preclinical evaluation of anticancer efficacy and pharmacological properties of FBA-TPQ, a novel synthetic makaluvamine analog.Marine drugs · 2012Article
- Preclinical pharmacology of BA-TPQ, a novel synthetic iminoquinone anticancer agent.Marine drugs · 2010Article
- Isolation, synthesis, and biological activity of aphrocallistin, an adenine-substituted bromotyramine metabolite from the Hexactinellida sponge Aphrocallistes beatrix.Journal of natural products · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Pancreatic cancer is the fourth leading cause of cancer death in the United States. The prognosis of the disease is very negative, because the cancer will be usually metastasized by the time a patient manifests symptoms. Although combination therapy shows some promise, new drugs to treat the disease are needed. Given our interest in finding new therapies for pancreatic cancer, we sought to determine whether the known cytotoxic activity of the batzellines extended to pancreatic cancer cell lines. The batzellines are pyrroloiminoquinones alkaloids obtained from the deep-water Caribbean sponge Batzella sp (family Esperiopsidae, order Poecilosclerida). We show here that batzellines exhibit selective cytotoxicity towards the pancreatic cancer cell lines AsPC-1, Panc-1, BxPC-3, and MIA PaCa2 compared with the normal African green monkey kidney epithelial cell line Vero. The batzellines cause cytotoxicity by inducing cell cycle arrest that is mediated by their ability to intercalate into DNA and/or inhibit topoisomerase II activity. The cytotoxic abilities of isobatzellines A and C against pancreatic cancer cell lines, their low toxicity against normal cells, and their reported ability to be synthesized makes them interesting compounds with potential chemotherapeutic effects that may merit further research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.