ArticlePhysical biology2009
What have we learned from the studies of two-state folders, and what are the unanswered questions about two-state protein folding?
Article in Physical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Selection for Folding Stability Predicts Observed Covariation Between Protein Positions in the PDB.Journal of molecular evolution · 2026Article
- Identification of an on-pathway intermediate illuminates the kinetic competition between protein folding and misfolding.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Albumin/Mitotane Interaction Affects Drug Activity in Adrenocortical Carcinoma Cells: Smoke and Mirrors on Mitotane Effect with Possible Implications for Patients' Management.International journal of molecular sciences · 2023Article
- The Molten Globule, and Two-State vs. Non-Two-State Folding of Globular Proteins.Biomolecules · 2020Review
- Heterogeneity in the Folding of Villin Headpiece Subdomain HP36.The journal of physical chemistry. B · 2018Article
- Modulating long-range energetics via helix stabilization: A case study using T4 lysozyme.Protein science : a publication of the Protein Society · 2018Article
- Identification and Characterization of an Inside-Out Folding Intermediate of T4 Phage Sliding Clamp.Biophysical journal · 2017Article
- How cooperative are protein folding and unfolding transitions?Protein science : a publication of the Protein Society · 2016Review
- The Folding of de Novo Designed Protein DS119 via Molecular Dynamics Simulations.International journal of molecular sciences · 2016Article
- Protein domain definition should allow for conditional disorder.Protein science : a publication of the Protein Society · 2013Article
- How long does it take to equilibrate the unfolded state of a protein?Protein science : a publication of the Protein Society · 2013Article
- Probing the origins of two-state folding.The Journal of chemical physics · 2013Article
- Reassessing the folding of the KIX domain: evidence for a two-state mechanism.Protein science : a publication of the Protein Society · 2012Article
- Thermodynamics of protein folding using a modified Wako-Saitô-Muñoz-Eaton model.Journal of biological physics · 2012Article
- Article
- Protein folded states are kinetic hubs.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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Abstract
Small proteins with globular structures often fold by simple all-or-none mechanisms, both in an equilibrium and a kinetic sense, despite the very large number of partly folded conformations available. This type of 'two-state' folding will be discussed in terms of experimental tests, underlying molecular mechanisms, and limits to two-state behavior. Factors that appear to be important for two-state folding include topology (sequence distance of contacts in the native structure), molecular cooperativity and local energy distribution. Because their local stability distributions and cooperativities can be dissected and analyzed separately from topological features, recent studies of the folding of symmetric proteins will be discussed as a means to better understand the origins of two-state folding.
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