ReviewPhysiological genomics2009
How form follows functional genomics: gene expression profiling gastric epithelial cells with a particular discourse on the parietal cell.
Review in Physiological genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- CD36 maintains the gastric mucosa and associates with gastric disease.Communications biology · 2021Article
- Tuft Cells Increase Following Ovine Intestinal Parasite Infections and Define Evolutionarily Conserved and Divergent Responses.Frontiers in immunology · 2021Article
- Increased expression of hypoxia inducible factor-1 alpha and vascular endothelial growth factor is associated with diabetic gastroparesis.BMC gastroenterology · 2020Article
- Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer.Nature reviews. Gastroenterology & hepatology · 2018Review
- A single transcription factor is sufficient to induce and maintain secretory cell architecture.Genes & development · 2017Article
- Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer.The Journal of pathology · 2015Article
- Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption.PLoS genetics · 2015Article
- The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation.The Journal of clinical investigation · 2013Article
- IFNγ contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice.Laboratory investigation; a journal of technical methods and pathology · 2012Article
- Production of ectopic gastric intrinsic factor in gastric mucosa of humans with chronic gastritis.Digestive diseases and sciences · 2011Article
- Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells.Physiological genomics · 2011Article
- The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.The American journal of pathology · 2010Article
- Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of "floxed" alleles.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.Molecular and cellular biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The cellular composition and morphology of the stomach epithelium have been described in detail; however, the molecular mechanisms that regulate the differentiation of the various cell lineages as well as the function of mature gastric cells are far less clear. Recently, dissection of the molecular anatomy of the stomach has been boosted by the advent of functional genomics, which allows investigators to determine patterns of gene expression across virtually the entire cellular transcriptome. In this review, we discuss the impact of functional genomic studies on the understanding of gastric epithelial physiology. We show how functional genomic studies have uncovered genes that are useful as new cell lineage-specific markers of differentiation and provide new insights into cell physiology. For example, vascular endothelial growth factor B (Vegfb) has been identified as a parietal cell-specific marker that may allow parietal cells to regulate the mucosal vascular network. We also discuss how functional genomics has identified aberrantly expressed genes in disease states. Human epididymis 4 (HE4), for example, was recently identified as a metaplasia-induced gene product in mice based on microarray analysis. Finally, we will examine how analysis of higher-order patterns of gene expression can go beyond simply identifying individual genes to show how cells work as integrated systems. Specifically, we show how application of a Gene Ontology (GO) analysis of gene expression patterns from multiple tissues identifies the gastric parietal cell as an outlier, unlike other differentiated cell lineages in the stomach or elsewhere in the body.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.