ArticleBiology of reproduction2009
Regulation of facilitative glucose transporters and AKT/MAPK/PRKAA signaling via estradiol and progesterone in the mouse uterine epithelium.
Article in Biology of reproduction, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Phenotype-specific efficacy of letrozole versus clomiphene citrate in polycystic ovary syndrome: a prospective cohort study.BMC women's health · 2026Article
- Glucose metabolism and endometrium decidualization.Frontiers in endocrinology · 2025Review
- Progesterone increases metabolism via the pentose phosphate pathway in bovine uterine epithelial cells.Molecular biology reports · 2024Article
- Impact of dehydroepiandrosterone sulfate and free androgen index on pregnancy and neonatal outcomes in PCOS patients.Reproductive biology and endocrinology : RB&E · 2024Article
- Recurrent Implantation Failure: Bioinformatic Discovery of Biomarkers and Identification of Metabolic Subtypes.International journal of molecular sciences · 2023Article
- Transcriptional response of endometrial cells to Insulin, cultured using microfluidics.Reproduction & fertility · 2023Article
- Energy metabolism and maternal-fetal tolerance working in decidualization.Frontiers in immunology · 2023Review
- An Update on the Progress of Endometrial Receptivity in Women with Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Glucose transporters: Important regulators of endometrial cancer therapy sensitivity.Frontiers in oncology · 2022Review
- Article
- Endometrial Glucose Transporters in Health and Disease.Frontiers in cell and developmental biology · 2021Review
- GLUT4 in Mouse Endometrial Epithelium: Roles in Embryonic Development and Implantation.Frontiers in physiology · 2021Article
- Glucose transporter 1 is important for the glycolytic metabolism of human endometrial stromal cells in hypoxic environment.Heliyon · 2020Article
- AMPK is required for uterine receptivity and normal responses to steroid hormones.Reproduction (Cambridge, England) · 2020Article
- The Notch Family Transcription Factor, RBPJκ, Modulates Glucose Transporter and Ovarian Steroid Hormone Receptor Expression During Decidualization.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Glycogen metabolism in mink uterine epithelial cells and its regulation by estradiol, progesterone and insulin.Theriogenology · 2019Article
- A functional role for AMPK in female fertility and endometrial regeneration.Reproduction (Cambridge, England) · 2018Article
- Mechanisms for the establishment and maintenance of pregnancy: synergies from scientific collaborations.Biology of reproduction · 2018Review
- Hypoxia increases glucose transporter 1 expression in bovine corpus luteum at the early luteal stage.The Journal of veterinary medical science · 2017Article
- Endometrial microbiome at the time of embryo transfer: next-generation sequencing of the 16S ribosomal subunit.Journal of assisted reproduction and genetics · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adequate uterine glucose metabolism is an essential part of embryo implantation and the development of an adequate utero-fetal environment. However, expression of facilitative glucose transporters (GLUTs [solute transporter family SLC2A]) and AKT/MAPK/PRKAA (PRKAA) signaling has not been described in the mouse uterine cells, to our knowledge. The objective of this study was to determine the hormonal regulation of SLC2A protein expression and AKT/MAPK/PRKAA signaling in the mouse uterine epithelial cells during estrous cycles and peri-implantation periods. SLC2As 1, 4, 8, and 9B were highly expressed in the luminal and glandular epithelia of estrous stage. In metestrous and diestrous stages, expression of SLC2As 1, 4, 8, and 9B was lower than that in proestrous stage. Levels of activated phospho-AKT (p-AKT), p-MAPK3, and p-MAPK1 also varied during the estrous cycle. Estrogen and progesterone injection in an ovariectomized mouse (delayed implantation model) resulted in a decrease and an increase, respectively, in expression of GLUTs in the luminal epithelial cells of the uterus. The expression of SLC2A1, SLC2A8, SLC2A9B, p-AKT, p-MAPK3/1, and p-PRKAA was increased in the decidual region of the implantation sites and was significantly increased in the uterus of activated implantation. Using an artificial decidualization mouse model, it was also demonstrated that expression of the same GLUTs, p-MAPK3/1, and p-PRKAA was dramatically higher in the decidualized uteri than that in the control uteri. These results suggest that steroid hormones regulate expression of uterine epithelial GLUTs possibly through AKT/MAPK/PRKAA signaling pathways and that glucose utilization may have an important role in decidualization and possibly in the maintenance of pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.