ArticleGenesis (New York, N.Y. : 2000)2009
Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.
Article in Genesis (New York, N.Y. : 2000), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Screening for mouse genes lost in mammals with long lifespans.BioData mining · 2019Article
- Mouse models of breast cancer.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.Molecular and cellular biology · 2014Article
- Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.PloS one · 2013Article
- Remodeling of endogenous mammary epithelium by breast cancer stem cells.Stem cells (Dayton, Ohio) · 2012Article
- Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice.BMC cancer · 2012Article
- Article
- Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.Cancer research · 2011Article
- Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.Transgenic research · 2010Article
- Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.Molecular and cellular biology · 2010Article
- VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.The American journal of pathology · 2010Article
- The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation.Development (Cambridge, England) · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We generated a novel mouse model, which expresses the tetracycline-inducible transactivator under the regulation of the endogenous whey acidic protein gene. Using a tet-responsive luciferase reporter transgene, we demonstrated that the Wap-rtTA knockin allele allows a tightly controlled temporal and spatial expression of transgenes in the mammary gland in a ligand-inducible manner. The longitudinal analysis of individual females throughout their reproductive cycles using in vivo bioluminescence imaging confirmed that the expression of the Wap-rtTA knockin allele is highly upregulated during lactation. However, the extent of the transcriptional activation of the targeted Wap locus is dependent on the suckling stimulus and milk retrieval. In addition, we used WAP-rtTA/TetO-H2B-GFP double-transgenic females to monitor the presence of GFP-labeled parity-induced mammary epithelial cells (PI-MECs) during the postlactational involution period. The study shows that, unlike their progeny in mammary epithelial transplants as reported previously, PI-MECs themselves may not belong to the long-term label-retaining epithelial subtype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.