ArticleGastroenterology2009
Retracted: Up-regulation of anterior cingulate cortex NR2B receptors contributes to visceral pain responses in rats.
Article in Gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease.World journal of gastroenterology · 2025Article
- Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome.Purinergic signalling · 2023Article
- Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats.iScience · 2023Article
- Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats.Communications biology · 2023Article
- Astrocyte L-Lactate Signaling in the ACC Regulates Visceral Pain Aversive Memory in Rats.Cells · 2022Article
- Identification of a Glutamatergic Claustrum-Anterior Cingulate Cortex Circuit for Visceral Pain Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats.Neuroscience bulletin · 2022Article
- Supraspinal Mechanisms of Intestinal Hypersensitivity.Cellular and molecular neurobiology · 2022Review
- Trigeminal neuropathy causes hypomyelination in the anterior cingulate cortex, disrupts the synchrony of neural circuitry, and impairs decision-making in male rats.Journal of neuroscience research · 2021Article
- Suppression of Pain in the Late Phase of Chronic Trigeminal Neuropathic Pain Failed to Rescue the Decision-Making Deficits in Rats.International journal of molecular sciences · 2021Article
- Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex.Journal of neurophysiology · 2021Article
- Role of the Anterior Cingulate Cortex in Translational Pain Research.Neuroscience bulletin · 2021Review
- Pathophysiologic Role of Neurotransmitters in Digestive Diseases.Frontiers in physiology · 2021Review
- NMDAR Neurotransmission Needed for Persistent Neuronal Firing: Potential Roles in Mental Disorders.Frontiers in psychiatry · 2021Review
- Schema-like learning and memory consolidation acting through myelination.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression.Scientific reports · 2018Article
- Dai-Kenchu-To, a Herbal Medicine, Attenuates Colorectal Distention-induced Visceromotor Responses in Rats.Journal of neurogastroenterology and motility · 2016Article
- Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish.CNS spectrums · 2016Review
- Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain.Molecular brain · 2015Article
- KATP channels in the nodose ganglia mediate the orexigenic actions of ghrelin.The Journal of physiology · 2015Article
Corrections and comments
- Retraction · 2024-01-10Falsification/Fabrication of Image · Investigation by Company/Institution · · See also: https://pubpeer.com/publications/0976C824D2FC1A05A70A8C41F2A810
- Retracted
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsElectrophysiologic and behavioral studies have shown that increased N-methyl-D-aspartate (NMDA)-receptor activation of anterior cingulate cortex (ACC) neurons has a critical role in modulating visceral pain responses in viscerally hypersensitive (VH) rats. This study aimed to identify the NMDA receptor subtypes in perigenual ACC (pACC) neurons involved in the facilitation of visceral nociception.
methodsWe performed in vivo electrophysiologic recordings of pACC neurons and examined the visceromotor response (VMR) to colorectal distention (CRD) in normal and VH rats induced by colonic anaphylaxis. The NR2A-subtype-receptor antagonist [(R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) and the NR2B-receptor-antagonist Ro25-6981 were microinjected into the pACC. To down-regulate NR2B-receptor gene expression, an NR2B-specific small interfering RNA (siRNA) and a plasmid (pEGFP-N1) that expressed the green fluorescent protein were administered into ACC neurons by electroporation.
resultsReverse microdialysis of NVP-AAM077 had no effect on basal and CRD-induced ACC neuronal firing in VH and control groups. In VH rats, Ro25-6981 (500 micromol/L) inhibited ACC neuronal firing, evoked by 30 and 50 mm Hg CRD, by 98% and 52%, respectively. NVP-AAM077 did not affect the VMR in either group. Ro25-6981 significantly suppressed the VMR in VH but not normal rats. Immunoblot analysis showed increased NR2B-receptor expression in the pACC of VH rats. NR2B siRNA-treated VH rats showed a significant reduction in the VMR, compared with controls.
conclusionsThe NR2B subunit of the NMDA receptor has a critical role in the modulation of ACC sensitization and visceral pain responses in VH rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.