ArticleJournal of anatomy2009
Extracellular matrix remodelling in human diabetic neuropathy.
Article in Journal of anatomy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy.The Journal of clinical investigation · 2025Article
- Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy.bioRxiv : the preprint server for biology · 2024Article
- Nerve decompression for diabetic peripheral neuropathy with nerve entrapment: a narrative review.Therapeutic advances in neurological disorders · 2024Review
- Effect of Hesperidin on Sciatic Nerve Damage in STZ-Induced Diabetic Neuropathy: Modulation of TRPM2 Channel.Neurotoxicity research · 2023Article
- Collagen turnover is associated with cardiovascular autonomic and peripheral neuropathy in type 1 diabetes: novel pathophysiological mechanism?Cardiovascular diabetology · 2023Article
- Effect of Surgical Release of Entrapped Peripheral Nerves in Sensorimotor Diabetic Neuropathy on Pain and Sensory Dysfunction-Study Protocol of a Prospective, Controlled Clinical Trial.Journal of personalized medicine · 2023Article
- Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.Frontiers in endocrinology · 2023Article
- Implications of fibrotic extracellular matrix in diabetic retinopathy.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Progressive multifocal fibrosing neuropathy: description of a novel disease.Acta neuropathologica communications · 2022Article
- Diabetes-related intestinal region-specific thickening of ganglionic basement membrane and regionally decreased matrix metalloproteinase 9 expression in myenteric ganglia.World journal of diabetes · 2021Article
- Genome-wide profiling of DNA methylation and gene expression identifies candidate genes for human diabetic neuropathy.Clinical epigenetics · 2020Article
- Matrix metalloproteinase 7 promoted Schwann cell migration and myelination after rat sciatic nerve injury.Molecular brain · 2019Article
- Pathway crosstalk perturbation network modeling for identification of connectivity changes induced by diabetic neuropathy and pioglitazone.BMC systems biology · 2019Article
- Collagen VI in healthy and diseased nervous system.Disease models & mechanisms · 2018Review
- Brain heparan sulphate proteoglycans are altered in developing foetus when exposed to in-utero hyperglycaemia.Metabolic brain disease · 2017Article
- Serum prolidase enzyme activity and oxidative stress levels in patients with diabetic neuropathy.Endocrine · 2014Article
- Characterization of Endoneurial Fibroblast-like Cells from Human and Rat Peripheral Nerves.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Article
- Morphometric analysis of connective tissue sheaths of sural nerve in diabetic and nondiabetic patients.BioMed research international · 2014Article
- The pattern of tibial nerve excursion with active ankle dorsiflexion is different in older people with diabetes mellitus.Clinical biomechanics (Bristol, Avon) · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular matrix of peripheral nerve plays a vital role in terms of normal nerve fibre function and also in the regenerative response following nerve injury. Nerve fibre loss is a major feature of diabetic neuropathy; however, the regenerative response is limited and this may be associated with changes in the composition of the extracellular matrix. Glycoproteins and collagens are major components of the extracellular matrix and are known to be important in terms of axonal growth. This work has therefore examined whether changes in the expression of two major glycoproteins, laminin and tenascin, and three collagen types (IV, V and VI) occur in the endoneurial and perineurial connective tissue compartments of human diabetic nerve. Despite being known to have a positive effect in terms of axonal growth, laminin levels were not elevated in the diabetic nerves. However, the pattern of tenascin expression did differ between the two groups being found in association with axon myelin units in the diabetic samples only. The pattern of collagen IV expression was the same in both tissue groups and was not found to be up-regulated. However, levels of collagen V and VI were both significantly increased in the endoneurium and for collagen VI also in the perineurium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.