ReviewJournal of neuroendocrinology2009
Rapid action of oestrogen in luteinising hormone-releasing hormone neurones: the role of GPR30.
Review in Journal of neuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Cellular and molecular features of EDC exposure: consequences for the GnRH network.Nature reviews. Endocrinology · 2021Review
- Gonadal Cycle-Dependent Expression of Genes Encoding Peptide-, Growth Factor-, and Orphan G-Protein-Coupled Receptors in Gonadotropin- Releasing Hormone Neurons of Mice.Frontiers in molecular neuroscience · 2020Article
- Review
- Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity.Hormones and behavior · 2018Review
- Reconsidering the roles of endogenous estrogens and xenoestrogens: the membrane estradiol receptor G protein-coupled receptor 30 (GPR30) mediates the effects of various estrogens.The Journal of reproduction and development · 2018Article
- Estradiol-Dependent Stimulation and Suppression of Gonadotropin-Releasing Hormone Neuron Firing Activity by Corticotropin-Releasing Hormone in Female Mice.Endocrinology · 2018Article
- GPR30 mediates estrone, estriol, and estradiol to suppress gonadotropin-releasing hormone-induced luteinizing hormone secretion in the anterior pituitary of heifers.The Journal of reproduction and development · 2017Article
- Altered Expression of Genes Encoding Neurotransmitter Receptors in GnRH Neurons of Proestrous Mice.Frontiers in cellular neuroscience · 2016Article
- International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators.Pharmacological reviews · 2015Review
- GnRH agonist reduces estrogen receptor dimerization in GT1-7 cells: evidence for cross-talk between membrane-initiated estrogen and GnRH signaling.Molecular and cellular endocrinology · 2015Article
- Palmitoylation of estrogen receptors is essential for neuronal membrane signaling.Endocrinology · 2013Article
- Neuroprotective effects of estradiol on motoneurons in a model of rat spinal cord embryonic explants.Cellular and molecular neurobiology · 2013Article
- G protein-coupled estrogen receptor in energy homeostasis and obesity pathogenesis.Progress in molecular biology and translational science · 2013Review
- Calcium signaling in mammalian egg activation and embryo development: the influence of subcellular localization.Molecular reproduction and development · 2012Review
- Estradiol signaling in the regulation of reproduction and energy balance.Frontiers in neuroendocrinology · 2012Review
- Rapid nongenomic effects of oestradiol on gonadotrophin-releasing hormone neurones.Journal of neuroendocrinology · 2012Review
- Estrogen receptors stimulate brain region specific metabotropic glutamate receptors to rapidly initiate signal transduction pathways.Journal of chemical neuroanatomy · 2011Review
- Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors.Acta physiologica (Oxford, England) · 2011Review
- The G-protein-coupled estrogen receptor GPER in health and disease.Nature reviews. Endocrinology · 2011Review
- Rapid action of estradiol in primate GnRH neurons: the role of estrogen receptor alpha and estrogen receptor beta.Steroids · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previously, we have shown that 17beta-oestradiol (E(2)) induces an increase in firing activity and modifies the pattern of intracellular calcium ([Ca(2+)](i)) oscillations with a latency < 1 min in primate luteinising hormone-releasing hormone (LHRH) neurones. A recent study also indicates that E(2), the nuclear membrane impermeable oestrogen, oestrogen-dendrimer conjugate, and the plasma membrane impermeable oestrogen, E(2)-BSA conjugate, all similarly stimulated LHRH release within 10 min of exposure in primate LHRH neurones, indicating that the rapid action of E(2) is caused by membrane signalling. The results from a series of studies further suggest that the rapid action of E(2) in primate LHRH neurones appears to be mediated by GPR30. Although the oestrogen receptor antagonist, ICI 182, 780, neither blocked the E(2)-induced LHRH release nor the E(2)-induced changes in [Ca(2+)](i) oscillations, E(2) application to cells treated with pertussis toxin failed to result in these changes in primate LHRH neurones. Moreover, knockdown of GPR30 in primate LHRH neurones by transfection with human small interference RNA for GPR30 completely abrogated the E(2)-induced changes in [Ca(2+)](i) oscillations, whereas transfection with control siRNA did not. Finally, the GPR30 agonist, G1, resulted in changes in [Ca(2+)](i) oscillations similar to those observed with E(2). In this review, we discuss the possible role of G-protein coupled receptors in the rapid action of oestrogen in neuronal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.