ArticleHepatology research : the official journal of the Japan Society of Hepatology2009
Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells.
Article in Hepatology research : the official journal of the Japan Society of Hepatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Towards Cost-Effective and Sustainable Media Formulations for Terrestrial and Aquatic Cellular Agriculture.Foods (Basel, Switzerland) · 2026Review
- Team players in the pathogenesis of metabolic dysfunctions-associated steatotic liver disease: The basis of development of pharmacotherapy.World journal of gastrointestinal pathophysiology · 2024Review
- Sphingosine-1-phosphate promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis.PloS one · 2024Article
- Resveratrol reduces platelet storage lesion by preventing free mitochondrial DNA (mtDNA) accumulation in platelet concentrates during storage.Journal of thrombosis and thrombolysis · 2023Article
- Mechanisms of liver fibrosis in metabolic syndrome.eGastroenterology · 2023Article
- A New Murine Liver Fibrosis Model Induced by Polyhexamethylene Guanidine-Phosphate.Biomolecules & therapeutics · 2022Article
- A Lard and Soybean Oil Mixture Alleviates Low-Fat-High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.Nutrients · 2022Article
- Therapeutic Applications of Resveratrol in Hepatic Encephalopathy through Its Regulation of the Microbiota, Brain Edema, and Inflammation.Journal of clinical medicine · 2021Review
- Alcohol consumption leads to loss of healthy life, but theHepatobiliary surgery and nutrition · 2021Article
- The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials.Nutrients · 2021Review
- 3,5-Diethoxy-3'-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury.Molecules (Basel, Switzerland) · 2018Article
- Long-chain fatty acid activates hepatocytes through CD36 mediated oxidative stress.Lipids in health and disease · 2018Article
- NASH Cirrhosis - the New Burden in Liver Transplantation: How Should It Be Managed?Visceral medicine · 2016Review
- Resveratrol and liver: A systematic review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- Roles of alcohol drinking pattern in fatty liver in Japanese women.Hepatology international · 2013Article
- Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.PloS one · 2013Article
- Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease.BMC gastroenterology · 2012Article
- Mechanisms of hepatic fibrogenesis.Best practice & research. Clinical gastroenterology · 2011Review
- An antioxidant resveratrol significantly enhanced replication of hepatitis C virus.World journal of gastroenterology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
aimTo ascertain whether resveratrol affects the expression of free fatty acids (FFA)-induced profibrogenic genes, death receptors, and/or apoptosis-related molecules in human hepatic stellate cells, using the LX-2 cell line.
methodsCells were cultured in the presence of FFAs (2:1 oleate : palmitate) and subsequently treated with resveratrol. Gene expression rates were determined by quantitative real-time PCR. The 50% lethal dose (LD(50)) of resveratrol in the presence of FFAs was assessed with the MTT viability test.
resultsCompared to vehicle controls, incubation of LX-2 cells with 0.5 mM FFAs induced profibrogenic genes (alpha-SMA x 2.9; TGF-beta1 x 1.6; TIMP-1 x 1.4), death receptors (CD95/Fas x 3.8; TNFR-1 x 1.4), and anti-apoptotic molecules (Bcl-2 x 2.3; Mcl-1 x 1.3). Subsequent addition of 15 microM resveratrol (LD(50) = 23.2 microM) significantly (P < 0.05) upregulated further these genes (alpha-SMA x 6.5; TGF-beta1 x 1.9; TIMP-1 x 2.2; CD95/Fas x 13.1, TNFR-1 x 2.1; Bcl-2 x 3.6; Mcl-1 x 1.9). Importantly, this effect was only observed in the presence of FFAs.
conclusionResveratrol amplifies the profibrogenic activation of human hepatic LX-2 stellate cells. This finding raises the possibility that in obese patients with elevated FFAs reserveratrol could provoke hepatic fibrogenesis. In-vivo studies are necessary to further validate this conclusion.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.