ArticleJournal of the American Geriatrics Society2009
Angiotensin-converting enzyme inhibitor use and incident frailty in women aged 65 and older: prospective findings from the Women's Health Initiative Observational Study.
Article in Journal of the American Geriatrics Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Angiotensin-Converting Enzyme Inhibitors on Physical Function in Elderly Subjects: A Systematic Review and Meta-Analysis.Drugs & aging · 2015Pooled it
- ACE-inhibition and physical function: results from the Trial of Angiotensin-Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study.Journal of the American Medical Directors Association · 2010Trial
- Frailty Index Progression Around Hypertension Diagnosis in 14 Countries.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Management of Acute Coronary Syndromes in Older People: Comprehensive Review and Multidisciplinary Practice-Based Recommendations.Journal of clinical medicine · 2024Review
- Genome-Wide Analysis inGenes · 2022Article
- Renin-Angiotensin System Blockade Is Associated with Exercise Capacity, Sympathetic Activity, and Endothelial Function in Patients with Chronic Kidney Disease.Kidney & blood pressure research · 2022Article
- Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty: A Longitudinal Cohort Study.Drugs & aging · 2019Article
- G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old.Scientific reports · 2018Article
- The impact of age on the implementation of evidence-based medications in patients with coronary artery disease and its prognostic significance: a retrospective cohort study.BMC public health · 2018Article
- Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women.Journal of aging research · 2018Article
- Prescribing for frail older people.Australian prescriber · 2017Review
- The renin-angiotensin system and prevention of age-related functional decline: where are we now?Age (Dordrecht, Netherlands) · 2015Review
- Perioperative frailty.International anesthesiology clinics · 2014Article
- Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration.The Journal of biological chemistry · 2013Article
- Measures of frailty in population-based studies: an overview.BMC geriatrics · 2013Review
- Statins, angiotensin-converting enzyme inhibitors, and physical performance in older women.Journal of the American Geriatrics Society · 2012Article
- Medication use and functional status decline in older adults: a narrative review.The American journal of geriatric pharmacotherapy · 2011Review
- Angiotensin-converting enzyme inhibitor and statin use and incident mobility limitation in community-dwelling older adults: the Health, Aging and Body Composition study.Journal of the American Geriatrics Society · 2011Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesTo examine the associations between current use, duration, and potency of angiotensin-converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline.
designData were from the Women's Health Initiative Observational Study (WHI-OS), a prospective study conducted at 40 U.S. clinical centers.
participantsWomen aged 65 to 79 at baseline who were not frail (N=27,378). MEASUREMENTS: Current ACE inhibitor use was ascertained through direct inspection of medicine containers at baseline. Components of frailty were self-reported low physical function or impaired walking, exhaustion, low physical activity, and unintended weight. Frailty was ascertained through self-reported and physical measurements data at baseline and 3-year clinic contacts.
resultsBy the 3-year follow-up, 3,950 (14.4%) women had developed frailty. Current ACE inhibitor use had no association with incident frailty (multivariate adjusted odds ratio=0.96, 95% confidence interval=0.82-1.13). Duration and potency of ACE inhibitor use were also not significantly associated with incident frailty. A similar pattern of results was observed when incident cardiovascular disease events were studied as a separate outcome or when the sample was restricted to subjects with hypertension.
conclusionOverall, incidence of frailty was similar in current ACE inhibitor users and nonusers.
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Registered trials
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