Evidence map›Paper›PMID 19207025›Full record

ReviewPharmacogenomics2009

Methods for analysis in pharmacogenomics: lessons from the Pharmacogenetics Research Network Analysis Group.

Balaji S Srinivasan, Jinbo Chen, Cheng Cheng, David Conti, Shiwei Duan, Brooke L Fridley, Xiangjun Gu, Jonathan L Haines, Eric Jorgenson, Aldi Kraja and 6 more

Abstract readReview
In one paragraph

Review in Pharmacogenomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Balaji S SrinivasanStanford University, CA, USA.
Jinbo Chen
Cheng Cheng
David Conti
Shiwei Duan
Brooke L Fridley
Xiangjun Gu
Jonathan L Haines
Eric Jorgenson
Aldi Kraja
Jessica Lasky-Su
Lang Li
Andrei Rodin
Dai Wang
Mike Province
Marylyn D Ritchie

Funding

PHARMACOGENETICS OF MEMBRANE TRANSPORTERSU01GM061390 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIACOMINI, KATHLEEN M · 2000 to 2009
$29.2M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
PHARMACOGENOMICS OF ARRHYTHMIA THERAPYU01HL065962 · NHLBI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2001 to 2009
$24.8M
Pharmacogenomics and Risk of Cardiovascular DiseaseU01HL069757 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KRAUSS, RONALD M · 2001 to 2009
$24.7M
Pharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI COOPER-DEHOFF, RHONDA M, JOHNSON, JULIE A. · 2005 to 2014
$20.7M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
PHARMACOGENETICS OF PHASE II DRUG METABOLIZING ENZYMESU01GM061388 · NIGMS · MAYO CLINIC ROCHESTER · PI WEINSHILBOUM, RICHARD M. · 2000 to 2009
$15.7M
Pharmacogenomics and Risk of Cardiovascular DiseaseU19HL069757 · NHLBI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI KRAUSS, RONALD M · 2010 to 2014
$12.8M
INHERITED VARIATIONS IN DRUG-METABOLIZING ENZYMESR01GM028157 · NIGMS · MAYO CLINIC ROCHESTER · PI WEINSHILBOUM, RICHARD M. · 1985 to 2019
$6.9M
Pulmonary Limitations in Chronic Heart FailureR01HL071478 · NHLBI · MAYO CLINIC ROCHESTER · PI JOHNSON, BRUCE D · 2002 to 2014
$3.7M
Anthipertensive PharmacoGenomicsR01HL074735 · NHLBI · MAYO CLINIC ROCHESTER · PI TURNER, STEPHEN T · 2003 to 2006
$3.4M
SULFATE CONJUGATION AND DRUG METABOLISMR01GM035720 · NIGMS · MAYO CLINIC ROCHESTER · PI WEINSHILBOUM, RICHARD M. · 1986 to 2007
$2.3M
NCATS NIH HHS UL1 TR000454NHLBI NIH HHS 5R01HL74735-01NHLBI NIH HHS HL65962NHLBI NIH HHS HL69757NHLBI NIH HHS R01 HL071478NHLBI NIH HHS R01 HL074735NHLBI NIH HHS R01 HL71478NHLBI NIH HHS U01 HL065962NHLBI NIH HHS U01 HL069757NHLBI NIH HHS U19 HL065962NHLBI NIH HHS U19 HL069757NIGMS NIH HHS 5U01GM074492-04NIGMS NIH HHS R01 GM028157NIGMS NIH HHS R01 GM035720NIGMS NIH HHS R01 GM28157NIGMS NIH HHS R01 GM35720NIGMS NIH HHS U01 GM061388NIGMS NIH HHS U01 GM061390NIGMS NIH HHS U01 GM074492NIGMS NIH HHS U01 GM61388NIGMS NIH HHS U01 GM61390NINDS NIH HHS N01 NS032352NINDS NIH HHS R01 NS32352
6 · The paper itself

Abstract

Each year, the Pharmacogenetics Research Network (PGRN) holds an analysis workshop for the members of the PGRN to share new methodologies, study design approaches and to discuss real data applications. This event is closed to members of the PGRN, but the methods presented are relevant to others conducting pharmacogenomics research. This special report describes many of the novel approaches discussed at the workshop and provides a resource for investigators in the field performing pharmacogenomics data analysis. While the focus is pharmacogenomics, the methods discussed are far ranging and have relevance to all types of genetic association studies: identifying noncoding variants and tag-SNPs, haplotype analysis, multivariate techniques, quantitative trait analysis, gene-gene and gene-environment interactions, and genome-wide association studies. The goal is to introduce readers to the topics discussed at the workshop and provide a direction for future development of analysis tools and methods for analysis of pharmacogenomic data.

Indexed as

Drug-Related Side Effects and Adverse ReactionsDrug TherapyEnvironmentGenetic VariationGenome, HumanGenome-Wide Association StudyGenotypeHumansModels, GeneticPharmacogeneticsPhenotype

Identifiers

PMID19207025
PMCPMC2737060

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.