ArticleACS nano2008
Live cell interferometry reveals cellular dynamism during force propagation.
Article in ACS nano, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Size Matters: Rethinking Hertz Model Interpretation for Cell Mechanics Using AFM.International journal of molecular sciences · 2024Article
- Drug screening at single-organoid resolution via bioprinting and interferometry.Nature communications · 2023Article
- Review
- Microfluidic Single-Cell Analytics.Advances in biochemical engineering/biotechnology · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- High-performance imaging of cell-substrate contacts using refractive index quantification microscopy.Biomedical optics express · 2020Article
- Cell viscoelasticity is linked to fluctuations in cell biomass distributions.Scientific reports · 2020Article
- Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics.Journal of visualized experiments : JoVE · 2018Article
- Membrane roughness as a sensitive parameter reflecting the status of neuronal cells in response to chemical and nanoparticle treatments.Journal of nanobiotechnology · 2016Article
- Live-cell mass profiling: an emerging approach in quantitative biophysics.Nature methods · 2014Article
- Membrane nanowaves in single and collective cell migration.PloS one · 2014Article
- Quantification of biomass and cell motion in human pluripotent stem cell colonies.Biophysical journal · 2013Article
- Rapid detection of bacterial resistance to antibiotics using AFM cantilevers as nanomechanical sensors.Nature nanotechnology · 2013Article
- Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity.PloS one · 2013Article
- Rapidly quantifying drug sensitivity of dispersed and clumped breast cancer cells by mass profiling.The Analyst · 2012Article
- Rapid, massively parallel single-cell drug response measurements via live cell interferometry.Biophysical journal · 2011Article
- Nanocharacterization in dentistry.International journal of molecular sciences · 2010Review
- Evaluation of bacteria-induced enamel demineralization using optical profilometry.Dental materials : official publication of the Academy of Dental Materials · 2009Article
- Mechanical interferometry of nanoscale motion and local mechanical properties of living zebrafish embryos.ACS nano · 2009Article
- Applicability of AFM in cancer detection.Nature nanotechnology · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cancer and many other diseases are characterized by changes in cell morphology, motion, and mechanical rigidity. However, in live cell cytology, stimulus-induced morphologic changes typically take 10-30 min to detect. Here, we employ live-cell interferometry (LCI) to visualize the rapid response of a whole cell to mechanical stimulation, on a time scale of seconds, and we detect cytoskeletal remodeling behavior within 200 s. This behavior involved small, rapid changes in cell content and miniscule changes in shape; it would be difficult to detect with conventional or phase contrast microscopy alone and is beyond the dynamic capability of AFM. We demonstrate that LCI provides a rapid, quantitative reconstruction of the cell body with no labeling. This is an advantage over traditional microscopy and flow cytometry, which require cell surface tagging and/or destructive cell fixation for labeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.