ArticleACS nano2008
Quantum dot-amphipol nanocomplex for intracellular delivery and real-time imaging of siRNA.
Article in ACS nano, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- Meta-analysis of cellular toxicity for cadmium-containing quantum dots.Nature nanotechnology · 2016Pooled it
- An insight into fluorescence and magnetic resonance bioimaging using a multifunctional polyethyleneimine-passivated gadocarbon dots nanoconstruct assembled with AS1411.Mikrochimica acta · 2023Article
- Review
- Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers.Pharmaceutics · 2021Review
- Small interfering RNA for cancer treatment: overcoming hurdles in delivery.Acta pharmaceutica Sinica. B · 2020Review
- Engineering functional inorganic-organic hybrid systems: advances in siRNA therapeutics.Chemical Society reviews · 2018Review
- Detection of K-ras gene mutations in feces by magnetic nanoprobe in patients with pancreatic cancer: A preliminary study.Experimental and therapeutic medicine · 2018Article
- Quantum dots-DNA bioconjugates: synthesis to applications.Interface focus · 2016Review
- Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications.Journal of visualized experiments : JoVE · 2016Article
- Amphiphilic polymer-coated CdSe/ZnS quantum dots induce pro-inflammatory cytokine expression in mouse lung epithelial cells and macrophages.Nanotoxicology · 2015Article
- Facilitated preparation of bioconjugatable zwitterionic quantum dots using dual-lipid encapsulation.Journal of colloid and interface science · 2015Article
- Current advances in polymer-based nanotheranostics for cancer treatment and diagnosis.ACS applied materials & interfaces · 2014Review
- Addressing Key Technical Aspects of Quantum Dot Probe Preparation for Bioassays.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2014Article
- Amphipols for each season.The Journal of membrane biology · 2014Review
- Nanoparticle-mediated systemic delivery of siRNA for treatment of cancers and viral infections.Theranostics · 2014Review
- Functional nanostructures for effective delivery of small interfering RNA therapeutics.Theranostics · 2014Review
- Coating barium titanate nanoparticles with polyethylenimine improves cellular uptake and allows for coupled imaging and gene delivery.Colloids and surfaces. B, Biointerfaces · 2013Article
- A universal protein tag for delivery of SiRNA-aptamer chimeras.Scientific reports · 2013Article
- Inorganic nanocrystals as contrast agents in MRI: synthesis, coating and introduction of multifunctionality.NMR in biomedicine · 2013Review
- Non-Viral Delivery and Therapeutic Application of Small Interfering RNAs.Acta naturae · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A new generation of nanoparticle carrier that allows efficient delivery and real-time imaging of siRNA in live cells has been developed by combining two distinct types of nanomaterials, semiconductor quantum dots and amphipols. An important finding is that, although amphipols are broadly used for solubilizing and delivering hydrophobic proteins into the lipid bilayers of cell membrane, when combined with nanoparticles, they offer previously undiscovered functionalities, including cytoplasm delivery, siRNA protection, and endosome escape. Compared with the classic siRNA carriers such as Lipofectamine and polyethyleneimine, this new class of nanocarrier works in both serum-free and complete cell culture media, which is advantageous over Lipofectamine. It also outperforms polyethyleneimine in gene silencing under both conditions with significantly reduced toxicity. Furthermore, the intrinsic fluorescence of quantum dots provides a mechanism for real-time imaging of siRNA delivery in live cells. This new multifunctional, compact, and traceable nanocarrier is expected to yield important information on rational design of siRNA carriers and to have widespread applications of siRNA delivery and screening in vitro and in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.