ArticleEvolutionary bioinformatics online2008
Estimation of genetic effects and genotype-phenotype maps.
Article in Evolutionary bioinformatics online, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Estimating directional epistasis.Frontiers in genetics · 2014Article
- MAPfastR: quantitative trait loci mapping in outbred line crosses.G3 (Bethesda, Md.) · 2013Article
- Monotonicity is a key feature of genotype-phenotype maps.Frontiers in genetics · 2013Article
- Current applications of models of genetic effects with interactions across the genome.Current genomics · 2012Article
- Multiallelic models of genetic effects and variance decomposition in non-equilibrium populations.Genetica · 2011Article
- Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2011Article
- Mapping QTLs with main and epistatic effects underlying grain yield and heading time in soft winter wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- Article
- Article
- Article
- Dissection of the genetic architecture of body weight in chicken reveals the impact of epistasis on domestication traits.Genetics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determining the genetic architecture of complex traits is a necessary step to understand phenotypic changes in natural, experimental and domestic populations. However, this is still a major challenge for modern genetics, since the estimation of genetic effects tends to be complicated by genetic interactions, which lead to changes in the effect of allelic substitutions depending on the genetic background. Recent progress in statistical tools aiming to describe and quantify genetic effects meaningfully improves the efficiency and the availability of genotype-to-phenotype mapping methods. In this contribution, we facilitate the practical use of the recently published 'NOIA' quantitative framework by providing an implementation of linear and multilinear regressions, change of reference operation and genotype-to-phenotype mapping in a package ('noia') for the software R, and we discuss theoretical and practical benefits evolutionary and quantitative geneticists may find in using proper modeling strategies to quantify the effects of genes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.