ArticleNature2009
Dynamic expression of epidermal caspase 8 simulates a wound healing response.
Article in Nature, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 163 citations in OpenAlex.
- Longitudinal proteomic analysis of GCF in regenerative healing of molar furcation degree II defects treated with OFD, EMD, or A-PRF + : a pilot study.Scientific reports · 2026Trial
- Dexamethasone reduces postoperative pain while delays wound healing in an animal model: Involvement of the NLRP3/Caspase-1/IL-1β pathway.BMC anesthesiology · 2026Article
- Article
- Innate Immune Sensors and Cell Death-Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin.Viruses · 2025Review
- Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Exploring caspase functions in mouse models.Apoptosis : an international journal on programmed cell death · 2024Review
- Cell death as an architect of adult skin stem cell niches.Cell death and differentiation · 2024Review
- Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions.The Journal of cell biology · 2024Article
- Article
- A Review on Caspases: Key Regulators of Biological Activities and Apoptosis.Molecular neurobiology · 2023Review
- Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.Science advances · 2023Article
- Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice.Inflammation and regeneration · 2023Article
- Role of Caspase-8 on Retinal Endothelial Cell Migration and Angiogenesis.Annals of vascular medicine and research · 2023Article
- Initiation of wound healing is regulated by the convergence of mechanical and epigenetic cues.PLoS biology · 2022Article
- Isolation and Quantification of Mouse γδT-cellsBio-protocol · 2021Article
- A systematic summary of survival and death signalling during the life of hair follicle stem cells.Stem cell research & therapy · 2021Review
- Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles.International journal of molecular sciences · 2021Article
- Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation.International journal of molecular sciences · 2021Review
- [Research advances on the mechanism of dendritic epidermal T lymphocytes in wound healing].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- The role of caspase-8 in the tumor microenvironment of ovarian cancer.Cancer metastasis reviews · 2021Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Tissue homeostasis and regeneration are regulated by an intricate balance of seemingly competing processes-proliferation versus differentiation, and cell death versus survival. Here we demonstrate that the loss of epidermal caspase 8, an important mediator of apoptosis, recapitulates several phases of a wound healing response in the mouse. The epidermal hyperplasia in the caspase 8 null skin is the culmination of signals exchanged between epidermal keratinocytes, dermal fibroblasts and leukocytic cells. This reciprocal interaction is initiated by the paracrine signalling of interleukin 1alpha (IL1alpha), which activates both skin stem cell proliferation and cutaneous inflammation. The non-canonical secretion of IL1alpha is induced by a p38-MAPK-mediated upregulation of NALP3 (also known as NLRP3), leading to inflammasome assembly and caspase 1 activation. Notably, the increased proliferation of basal keratinocytes is counterbalanced by the growth arrest of suprabasal keratinocytes in the stratified epidermis by IL1alpha-dependent NFkappaB signalling. Altogether, our findings illustrate how the loss of caspase 8 can affect more than programmed cell death to alter the local microenvironment and elicit processes common to wound repair and many neoplastic skin disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.