ArticleGenetics2009
Germline expression influences operon organization in the Caenorhabditis elegans genome.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Sperm activation for fertilization requires robust activity of the TAT-5 lipid flippase.Developmental biology · 2025Article
- Pervasive Conservation of Intron Number and Other Genetic Elements Revealed by a Chromosome-level Genome Assembly of the Hyper-polymorphic Nematode Caenorhabditis brenneri.Genome biology and evolution · 2025Article
- Pervasive conservation of intron number and other genetic elements revealed by a chromosome-level genomic assembly of the hyper-polymorphic nematodebioRxiv : the preprint server for biology · 2024Article
- Genome annotation of Caenorhabditis briggsae by TEC-RED identifies new exons, paralogs, and conserved and novel operons.G3 (Bethesda, Md.) · 2022Article
- The zinc-finger transcription factor LSL-1 is a major regulator of the germline transcriptional program in Caenorhabditis elegans.Genetics · 2022Article
- Systematic analysis of long intergenic non-coding RNAs inRNA biology · 2021Article
- Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans.Nature communications · 2020Article
- Distinctive regulatory architectures of germline-active and somatic genes inGenome research · 2020Article
- Resolution of polycistronic RNA by SL2RNA (New York, N.Y.) · 2020Article
- Males, Outcrossing, and Sexual Selection inGenetics · 2019Review
- Molecular evolution across developmental time reveals rapid divergence in early embryogenesis.Evolution letters · 2019Article
- Repression of Germline Genes inGenetics · 2019Article
- Early experiences mediate distinct adult gene expression and reproductive programs in Caenorhabditis elegans.PLoS genetics · 2018Article
- StableProceedings of the National Academy of Sciences of the United States of America · 2016Article
- Comparative functional characterization of the CSR-1 22G-RNA pathway in Caenorhabditis nematodes.Nucleic acids research · 2015Article
- Genome-wide analysis of trans-splicing in the nematode Pristionchus pacificus unravels conserved gene functions for germline and dauer development in divergent operons.RNA (New York, N.Y.) · 2014Article
- To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest.Genetics · 2013Review
- Spermatogenesis.Advances in experimental medicine and biology · 2013Review
- Trans-splicing and operons in C. elegans.WormBook : the online review of C. elegans biology · 2012Review
- emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.Genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Operons are found across multiple kingdoms and phyla, from prokaryotes to chordates. In the nematode Caenorhabditis elegans, the genome contains >1000 operons that compose approximately 15% of the protein-coding genes. However, determination of the force(s) promoting the origin and maintenance of operons in C. elegans has proved elusive. Compared to bacterial operons, genes within a C. elegans operon often show poor coexpression and only sometimes encode proteins with related functions. Using analysis of microarray and large-scale in situ hybridization data, we demonstrate that almost all operon-encoded genes are expressed in germline tissue. However, genes expressed during spermatogenesis are excluded from operons. Operons group together along chromosomes in local clusters that also contain monocistronic germline-expressed genes. Additionally, germline expression of genes in operons is largely independent of the molecular function of the encoded proteins. These analyses demonstrate that mechanisms governing germline gene expression influence operon origination and/or maintenance. Thus, gene expression in a specific tissue can have profound effects on the evolution of genome organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.