ArticleArchives of ophthalmology (Chicago, Ill. : 1960)2009
Serum cystatin C level, kidney disease markers, and incidence of age-related macular degeneration: the Beaver Dam Eye Study.
Article in Archives of ophthalmology (Chicago, Ill. : 1960), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
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- Chronic Kidney Disease as a Risk Factor for Age-Related Macular Degeneration: A Prospective Cohort and Mendelian Randomization Analyses.Ophthalmology science · 2026Article
- Impact of chronic kidney disease on the incidence of visual impairment and age-related eye diseases in a multi-ethnic Asian population.Journal of global health · 2025Article
- Potential Causal Effects of Cystatin C on Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study.Biomedicines · 2025Article
- Artificial intelligence-driven diagnosis for age-related macular degeneration bridging pathology and engineering: a survey.International ophthalmology · 2025Review
- High Ocular Disease Burden and Increased Referral Needs in Patients with Chronic Kidney Disease: A Step Toward Personalized Care.Journal of personalized medicine · 2025Article
- Chronic kidney disease enhances alternative pathway activity: a new paradigm.The Journal of clinical investigation · 2025Review
- Association between chronic kidney disease and age-related macular degeneration: a Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- Pars plana vitrectomy in patients aged 85 years and older: a single-centre, retrospective cohort study.International ophthalmology · 2023Article
- Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Increased end-stage renal disease risk in age-related macular degeneration: a nationwide cohort study with 10-year follow-up.Scientific reports · 2023Article
- Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes.Translational vision science & technology · 2022Article
- Association between chronic kidney disease and open-angle glaucoma in South Korea: a 12-year nationwide retrospective cohort study.Scientific reports · 2022Article
- Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy.Genes & diseases · 2022Review
- Genetics of 35 blood and urine biomarkers in the UK Biobank.Nature genetics · 2021Article
- Risk factors for progression of age-related macular degeneration.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2020Review
- Increased Rate of Retinal Pigment Epithelial Cell Migration and Pro-Angiogenic Potential Ensuing From Reduced Cystatin C Expression.Investigative ophthalmology & visual science · 2020Article
- Association Between Cystatin C and 20-Year Cumulative Incidence of Hearing Impairment in the Epidemiology of Hearing Loss Study.JAMA otolaryngology-- head & neck surgery · 2018Article
- Association between macular degeneration and mild to moderate chronic kidney disease: A nationwide population-based study.Medicine · 2017Observational
- The association of geographic atrophy and decreased renal function in patients with age-related macular degeneration.Eye (London, England) · 2017Article
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4 authors.
Funding
Abstract
objectiveTo examine the associations of the serum cystatin C level and chronic kidney disease with the incidence of age-related macular degeneration (AMD) over 15 years.
methodsIn this population-based cohort study of 4926 individuals aged 43 to 86 years at baseline, 3779 participated in 1 or more follow-up examinations. Age-related macular degeneration was determined by grading photographs of the macula. Individuals were defined as having mild or moderate to severe chronic kidney disease based on a value of more than 45 mL/min/1.73 m(2) to 60 mL/min/1.73 m(2) or less and 45 mL/min/1.73 m(2) or less, respectively, according to the Modification of Diet in Renal Disease Study equation.
resultsWhile controlling for age and other risk factors, the level of serum cystatin C at baseline was associated with the incidence of early AMD (odds ratio per log standard deviation [95% confidence interval], 1.16 [1.01-1.35]) and exudative AMD (1.42 [1.03-1.96]) but not geographic atrophy (0.89 [0.56-1.41]) or progression of AMD (1.02 [0.88-1.18]). Mild chronic kidney disease was associated with the 15-year cumulative incidence of early AMD (odds ratio per log standard deviation, 1.36 [95% confidence interval, 1.00-1.86]) but not the incidence of other AMD end points.
conclusionThere is a relationship between the level of serum cystatin C and chronic kidney disease with the incidence of AMD. The underlying biological processes remain to be determined.
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