Evidence map›Paper›PMID 19204107›Full record

ArticleThe Journal of experimental medicine2009

Rethinking T cell immunity in oropharyngeal candidiasis.

Liise-anne Pirofski, Arturo Casadevall

Abstract readComment
In one paragraph

Article in The Journal of experimental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Applying the Host-Microbe Damage Response Framework toJournal of fungi (Basel, Switzerland) · 2020
    Review
  6. Oral Candidiasis: A Disease of Opportunity.Journal of fungi (Basel, Switzerland) · 2020
    Review
  7. Mucosal IgA Prevents CommensalFrontiers in immunology · 2020
    Article
  8. Review
  9. Observational
  10. Review
  11. Article
  12. Article
  13. Clinical features of Candidiasis in patients with inherited interleukin 12 receptor β1 deficiency.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014
    Article
  14. Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis.Current opinion in allergy and clinical immunology · 2012
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Liise-anne PirofskiDepartment of Medicine, Albert Einstein College of Medicine College of Medicine, Bronx, NY, USA.
Arturo Casadevall

Funding

PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONSR01AI033774 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2014
$5.6M
Molecular Characterization of C. neoformans AntibodiesR37AI033142 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2007 to 2016
$3.9M
Human Antibodies to Crytococcus NeoformansR01AI035370 · NIAID · YESHIVA UNIVERSITY · PI PIROFSKI, LIISE-ANNE · 1994 to 2009
$3.3M
MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIESR01AI033142 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2006
$1.7M
NHLBI NIH HHS HL059843NIAID NIH HHS AI033142NIAID NIH HHS AI033774NIAID NIH HHS R01 AI033142NIAID NIH HHS R01 AI033774NIAID NIH HHS R01 AI035370NIAID NIH HHS R01AI035370NIAID NIH HHS R01AI04545NIAID NIH HHS R37 AI033142
6 · The paper itself

Abstract

The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.

Indexed as

Acquired Immunodeficiency SyndromeAnimalsCandidiasis, OralCD4-Positive T-LymphocytesDisease SusceptibilityHumansMice

Identifiers

PMID19204107
PMCPMC2646576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.