ReviewProceedings. Biological sciences2009
The causes of mutation accumulation in mitochondrial genomes.
Review in Proceedings. Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed.
- Disruption of mitonuclear coadaptation and compensatory evolution after an extreme dietary shift in carnivorous butterflies.Molecular biology and evolution · 2026Article
- Rapid and reproducible haplotyping of complete mitochondrial genomes using split k-mers.BMC genomics · 2026Article
- Sensitivity of genome-wide tests for mitonuclear genetic incompatibilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Positive and relaxed selection on mitochondrial DNA in parasitic versus predatory mites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Stronger Evidence for Relaxed Selection Than Adaptive Evolution in High-elevation Animal mtDNA.Molecular biology and evolution · 2025Article
- The dynamics of loss of heterozygosity events in genomes.EMBO reports · 2025Review
- Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists.PLoS pathogens · 2025Review
- Mitochondrial DNA Mutations and Epigenetic Regulation in Type 2 Diabetes Mellitus Development.British journal of biomedical science · 2025Review
- Article
- Convergent Mutations and Single Nucleotide Variants in Mitochondrial Genomes of Modern Humans and Neanderthals.International journal of molecular sciences · 2024Article
- Molecular characterization and demographic insights into soybean bud borer (Lepidoptera: Tortricidae) in Brazil.Journal of insect science (Online) · 2024Article
- Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world.Evolutionary applications · 2024Article
- Mitogenomic architecture and evolution of the soil ciliatesmSystems · 2024Article
- Stronger evidence for relaxed selection than adaptive evolution in high-elevation animal mtDNA.bioRxiv : the preprint server for biology · 2024Article
- Mother's Curse effects on lifespan and aging.Frontiers in aging · 2024Review
- Mitonuclear interactions modulate nutritional preference.Biology letters · 2023Article
- Review
- Disentangling Positive Selection from Relaxed Selection in Animal Mitochondrial Genomes.The American naturalist · 2023Article
- A chromosome-scale genome assembly and evaluation of mtDNA variation in the willow leaf beetle Chrysomela aeneicollis.G3 (Bethesda, Md.) · 2023Article
- Single-molecule Sequencing of an Animal Mitochondrial Genome Reveals Chloroplast-like Architecture and Repeat-mediated Recombination.Molecular biology and evolution · 2023Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A fundamental observation across eukaryotic taxa is that mitochondrial genomes have a higher load of deleterious mutations than nuclear genomes. Identifying the evolutionary forces that drive this difference is important to understanding the rates and patterns of sequence evolution, the efficacy of natural selection, the maintenance of sex and recombination and the mechanisms underlying human ageing and many diseases. Recent studies have implicated the presumed asexuality of mitochondrial genomes as responsible for their high mutational load. We review the current body of knowledge on mitochondrial mutation accumulation and recombination, and conclude that asexuality, per se, may not be the primary determinant of the high mutation load in mitochondrial DNA (mtDNA). Very little recombination is required to counter mutation accumulation, and recent evidence suggests that mitochondrial genomes do experience occasional recombination. Instead, a high rate of accumulation of mildly deleterious mutations in mtDNA may result from the small effective population size associated with effectively haploid inheritance. This type of transmission is nearly ubiquitous among mitochondrial genomes. We also describe an experimental framework using variation in mating system between closely related species to disentangle the root causes of mutation accumulation in mitochondrial genomes.
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