ArticleCell2009
DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance.
Article in Cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 80 citations in OpenAlex.
- Caspase-3 Levels Alter With Non-surgical Periodontal Therapy in Patients With Periodontitis.Cureus · 2024Article
- Caspase-2 mRNA levels are not elevated in mild cognitive impairment, Alzheimer's disease, Huntington's disease, or Lewy Body dementia.PloS one · 2022Article
- The Role of Caspase-2 in Regulating Cell Fate.Cells · 2020Review
- Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death.Scientific reports · 2020Article
- Lowering Etoposide Doses Shifts Cell Demise From Caspase-Dependent to Differentiation and Caspase-3-Independent Apoptosis via DNA Damage Response, Inducing AML Culture Extinction.Frontiers in pharmacology · 2018Article
- Long and short (timeframe) of endoplasmic reticulum stress-induced cell death.The FEBS journal · 2016Review
- Article
- The Golgi complex in stress and death.Frontiers in neuroscience · 2015Review
- Article
- Caspase functions in cell death and disease.Cold Spring Harbor perspectives in biology · 2013Review
- Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis.Frontiers in cellular and infection microbiology · 2013Article
- DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation.PloS one · 2013Article
- Characterization of DDRI-18 (3,3'-(1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response.British journal of pharmacology · 2012Article
- Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15.The Journal of clinical investigation · 2012Article
- The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients.Journal of autism and developmental disorders · 2012Article
- Cytoplasmic and nuclear anti-apoptotic roles of αB-crystallin in retinal pigment epithelial cells.PloS one · 2012Article
- Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks.Nucleic acids research · 2011Article
- Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1).Cell death and differentiation · 2011Article
- Caspases and cancer.Cell death and differentiation · 2011Review
- PIDD orchestrates translesion DNA synthesis in response to UV irradiation.Cell death and differentiation · 2011Article
Corrections and comments
- Retraction · 2011-04-01Error in Data · Error in Image · Error in Results and/or Conclusions ·
- Retracted
Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
Abstract
Caspase-2 is unique among all the mammalian caspases in that it is the only caspase that is present constitutively in the cell nucleus, in addition to other cellular compartments. However, the functional significance of this nuclear localization is unknown. Here we show that DNA damage induced by gamma-radiation triggers the phosphorylation of nuclear caspase-2 at the S122 site within its prodomain, leading to its cleavage and activation. This phosphorylation is carried out by the nuclear serine/threonine protein kinase DNA-PKcs and promoted by the p53-inducible death-domain-containing protein PIDD within a large nuclear protein complex consisting of DNA-PKcs, PIDD, and caspase-2, which we have named the DNA-PKcs-PIDDosome. This phosphorylation and the catalytic activity of caspase-2 are involved in the maintenance of a G2/M DNA damage checkpoint and DNA repair mediated by the nonhomologous end-joining (NHEJ) pathway. The DNA-PKcs-PIDDosome thus represents a protein complex that impacts mammalian G2/M DNA damage checkpoint and NHEJ.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.