ArticleMicrobiology (Reading, England)2009
Genes involved in the repression of mutacin I production in Streptococcus mutans.
Article in Microbiology (Reading, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Novel Probiotic Mechanisms of the Oral BacteriumApplied and environmental microbiology · 2019Article
- Carbohydrate and PepO control bimodality in competence development by Streptococcus mutans.Molecular microbiology · 2019Article
- Endopeptidase PepO Regulates the SpeB Cysteine Protease and Is Essential for the Virulence of Invasive M1T1 Streptococcus pyogenes.Journal of bacteriology · 2018Article
- Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans.Caries research · 2018Article
- Lantibiotic resistance.Microbiology and molecular biology reviews : MMBR · 2015Review
- Variable characteristics of bacteriocin-producing Streptococcus salivarius strains isolated from Malaysian subjects.PloS one · 2014Article
- Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level.Journal of oral microbiology · 2014Article
- Genetic variability of mutans streptococci revealed by wide whole-genome sequencing.BMC genomics · 2013Article
- Development of a LacZ-based transcriptional reporter system for use with Moraxella catarrhalis.Plasmid · 2013Article
- An extracelluar protease, SepM, generates functional competence-stimulating peptide in Streptococcus mutans UA159.Journal of bacteriology · 2012Article
- The mutacins of Streptococcus mutans: regulation and ecology.Molecular oral microbiology · 2012Review
- Mutacins of Streptococcus mutans.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- Antibacterial Peptides: Opportunities for the Prevention and Treatment of Dental Caries.Probiotics and antimicrobial proteins · 2011Article
- Genome-wide characterization of the SloR metalloregulome in Streptococcus mutans.Journal of bacteriology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Streptococcus mutans is considered a primary pathogen for human dental caries. Its ability to produce a variety of peptide antibiotics called mutacins may play an important role in its invasion and establishment in the dental biofilm. S. mutans strain UA140 produces two types of mutacins, the lantibiotic mutacin I and the non-lantibiotic mutacin IV. In a previous study, we constructed a random insertional-mutation library to screen for genes involved in regulating mutacin I production, and found 25 genes/operons that have a positive effect on mutacin I production. In this study, we continued our previous work to identify genes that are negatively involved in mutacin I production. By using a high-phosphate brain heart infusion agar medium that inhibited mutacin I production of the wild-type, we isolated 77 clones that consistently produced mutacin I under repressive conditions. From the 34 clones for which we were able to obtain a sequence, 17 unique genes were identified. These genes encompass a variety of functional groups, including central metabolism, surface binding and sugar transport, and unknown functions. Some of the 17 mutations were further characterized and shown to increase mutacin gene expression during growth when the gene is usually not expressed in the wild-type. These results further demonstrate an intimate and intricate connection between mutacin production and the overall cellular homeostasis.
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