ArticleProceedings of the National Academy of Sciences of the United States of America2009
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Analysis of Flurothyl-induced Seizures and Epileptogenesis in Mice with Targeted Deletions of Exons 3 and 4 in Dock7.bioRxiv : the preprint server for biology · 2026Article
- Deletion ofbioRxiv : the preprint server for biology · 2026Article
- Three NovelAnimals : an open access journal from MDPI · 2025Article
- PMEL p.Leu18del dilutes coat color of Kumamoto sub-breed of Japanese Brown cattle.BMC genomics · 2022Article
- Assessment of autism-relevant behaviors in C57BKS/J leptin receptor deficient mice.Hormones and behavior · 2021Article
- Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology.The Journal of investigative dermatology · 2019Review
- Mouse germ line mutations due to retrotransposon insertions.Mobile DNA · 2019Review
- Article
- Widespread DNA hypomethylation and differential gene expression in Turner syndrome.Scientific reports · 2016Article
- Brown adipose tissue and bone.International journal of obesity supplements · 2015Review
- Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.PLoS genetics · 2014Article
- Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness.American journal of human genetics · 2014Article
- Insights into the biological functions of Dock family guanine nucleotide exchange factors.Genes & development · 2014Article
- Dock protein family in brain development and neurological disease.Communicative & integrative biology · 2013Review
- Altered thermogenesis and impaired bone remodeling in Misty mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα.Molecular biology of the cell · 2013Article
- Atypical angiopoietin-like protein that regulates ANGPTL3.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.Nature neuroscience · 2012Article
- Sensory nerve induced inflammation contributes to heterotopic ossification.Journal of cellular biochemistry · 2011Article
- The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The classical recessive coat color mutation misty (m) arose spontaneously on the DBA/J background and causes generalized hypopigmentation and localized white-spotting in mice, with a lack of pigment on the belly, tail tip, and paws. Here we describe moonlight (mnlt), a second hypopigmentation and white-spotting mutation identified on the C57BL/6J background, which yields a phenotypic copy of m/m coat color traits. We demonstrate that the 2 mutations are allelic. m/m and mnlt/mnlt phenotypes both result from mutations that truncate the dedicator of cytokinesis 7 protein (DOCK7), a widely expressed Rho family guanine nucleotide exchange factor. Although Dock7 is transcribed at high levels in the developing brain and has been implicated in both axon development and myelination by in vitro studies, we find no requirement for DOCK7 in neurobehavioral function in vivo. However, DOCK7 has non-redundant role(s) related to the distribution and function of dermal and follicular melanocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.