ArticleAmerican journal of respiratory and critical care medicine2009
Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control.
Article in American journal of respiratory and critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats.Purinergic signalling · 2023Article
- P2XAmerican journal of physiology. Lung cellular and molecular physiology · 2023Article
- P2RX7 at the Host-Pathogen Interface of Infectious Diseases.Microbiology and molecular biology reviews : MMBR · 2021Review
- Oxidized-ATP Attenuates Kidney Allograft Rejection By Inhibiting T-Cell, B-Cell, and Macrophage Activity.Kidney360 · 2020Article
- Sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients.The Journal of allergy and clinical immunology · 2018Article
- Asthma Biomarkers: Do They Bring Precision Medicine Closer to the Clinic?Allergy, asthma & immunology research · 2017Review
- A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Personalized management of asthma exacerbations: lessons from genetic studies.Expert review of precision medicine and drug development · 2016Article
- Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2014Article
- Update in asthma 2013.American journal of respiratory and critical care medicine · 2014Review
- P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.PloS one · 2014Article
- Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-β production in murine macrophages.Journal of leukocyte biology · 2013Article
- Virus/allergen interactions in asthma.Current allergy and asthma reports · 2013Review
- P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.American journal of respiratory and critical care medicine · 2013Article
- Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7.American journal of respiratory cell and molecular biology · 2012Article
- Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function.The Journal of allergy and clinical immunology · 2012Article
- Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host.PloS one · 2012Article
- Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation.American journal of respiratory and critical care medicine · 2011Article
- Activation of beta1 integrins on blood eosinophils by P-selectin.American journal of respiratory cell and molecular biology · 2011Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleUpper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X(7) regulates compartmentalized acute inflammation and the immune response to airway pathogens.
objectivesWe hypothesized that variability in P2X(7) function contributes to neutrophilic airway inflammation during a cold and thereby is linked to acute asthma.
methodsResearch volunteers with asthma were enrolled at the onset of a naturally occurring cold and monitored through convalescence, assessing symptoms, lung function, and airway inflammation. P2X(7) pore activity in whole blood samples was measured using a genomically validated flow cytometric assay. MEASUREMENTS AND MAIN
resultsThirty-five participants with mild to moderate allergic asthma were enrolled and 31 completed all visits. P2X(7) pore function correlated with the change in nasal lavage neutrophil counts during the cold (R(s) = 0.514, P = 0.004) and was inversely related to the change in asthma symptoms (R(s) = -0.486, P = 0.009). The change in peak expiratory flow recordings, precold use of inhaled corticosteroids, and P2X(7) pore function were multivariate predictors of asthma symptoms (P = 0.001, < 0.001 and = 0.003 respectively). Attenuated P2X(7) activity was associated with the risk of losing asthma control (crude odds ratio, 11.0; 95% confidence interval, 1.1-106.4) even after adjustment for inhaled corticosteroids and rhinovirus (odds ratio, 15.0).
conclusionsA whole blood P2X(7) pore assay robustly identifies participants with loss-of-function genotypes. Using this assay as an epidemiologic tool, attenuated P2X(7) pore activity may be a novel biomarker of virus-induced loss of asthma control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.