ArticleJournal of bacteriology2009
The core oligosaccharide and thioredoxin of Vibrio cholerae are necessary for binding and propagation of its typing phage VP3.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Revisiting the Genomic Epidemiology of Distinct Phage-TypeMicroorganisms · 2025Article
- Overview of Phage Defense Systems in Bacteria and Their Applications.International journal of molecular sciences · 2024Review
- Variants of a putative baseplate wedge protein extend the host range of Pseudomonas phage K8.Microbiome · 2023Article
- Isolation and characterization of two homolog phages infectingFrontiers in microbiology · 2022Article
- A PolyQ Membrane Protein of Vibrio cholerae Acts as the Receptor for Phage Infection.Journal of virology · 2021Article
- The Type II Secretory System Mediates Phage Infection inFrontiers in cellular and infection microbiology · 2021Article
- The outer-membrane protein TolC ofThe Journal of biological chemistry · 2018Article
- Characterization of Pseudomonas aeruginosa Phage C11 and Identification of Host Genes Required for Virion Maturation.Scientific reports · 2016Article
- The Resistance of Vibrio cholerae O1 El Tor Strains to the Typing Phage 919TP, a Member of K139 Phage Family.Frontiers in microbiology · 2016Article
- Two functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways.Infection and immunity · 2014Article
- Arginine deiminase pathway is far more important than urease for acid resistance and intracellular survival in Laribacter hongkongensis: a possible result of arc gene cassette duplication.BMC microbiology · 2014Article
- O antigen is the receptor of Vibrio cholerae serogroup O1 El Tor typing phage VP4.Journal of bacteriology · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
VP3 is a T7-like phage and was used as one of the typing phages in a phage-biotyping scheme that has been used for the typing of Vibrio cholerae O1 biotype El Tor. Here, we studied the receptor and other host genes of V. cholerae necessary for the lytic propagation of VP3. Six mutants resistant to VP3 infection were obtained from the random transposon insertion mutant bank of the sensitive strain N16961. The genes VC0229 and VC0231, which belong to the wav gene cluster encoding the core oligosaccharide (OS) region of lipopolysaccharide, were found to be interrupted by the transposon in five mutants, and the sixth mutant had the transposon inserted between the genes rhlB and trxA, which encode the ATP-dependent RNA helicase RhlB and thioredoxin, respectively. Gene complementation, transcription analysis, and the loss of VP3 sensitivity by the gene deletion mutants confirmed the relationship between VP3 resistance and VC0229, VC0231, and trxA mutation. The product of VP3 gene 44 (gp44) was predicted to be a tail fiber protein. gp44 could bind to the sensitive wild-type strain and the trxA mutant, but not to VC0229 and VC0231 mutants. The results showed that OS is a VP3 receptor on the surface of N16961, thioredoxin of the host strain is involved in the propagation of the phage, and gp44 is the tail fiber protein of VP3. This revealed the first step in the infection mechanism of the T7-like phage VP3 in V. cholerae.
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