ArticleBiological psychiatry2009
Candidate endophenotypes for genetic studies of suicidal behavior.
Article in Biological psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02843997 (Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression), which is not on this map. Cited by 172 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression
Who cites it
172 citing papers in PubMed, 6 syntheses or guidelines pooled it, 402 citations in OpenAlex.
- Genome-wide association study meta-analysis of suicide death and suicidal behavior.Molecular psychiatry · 2023Pooled it
- Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review.Frontiers in psychiatry · 2022Pooled it
- [Prevalence and asociated factor for ideation and suicide attempt in adolescents: a systematic review.]Revista espanola de salud publica · 2020Pooled it
- Association between Catechol-O-Methyltransferase Val158Met (158G/A) Polymorphism and Suicide Susceptibility: A Meta-analysis.Journal of research in health sciences · 2017Pooled it
- Executive function and suicidality: A systematic qualitative review.Clinical psychology review · 2015Pooled it
- Association of the 5HTR2A gene with suicidal behavior: case-control study and updated meta-analysis.BMC psychiatry · 2013Pooled it
- Attentional control may be modifiable with Mindfulness-Based Cognitive Therapy to Prevent Suicide.Behaviour research and therapy · 2021Trial
- Mindfulness-Based Cognitive Therapy for Preventing Suicide in Military Veterans: A Randomized Clinical Trial.The Journal of clinical psychiatry · 2021Trial
- Auditory evoked potentials and suicidal behaviors in patients with major depressive disorders.Scientific reports · 2021Trial
- Acute risk factors for suicide attempts and death: prospective findings from the STEP-BD study.Bipolar disorders · 2016Trial
- Penetrating neck trauma and the rising rates of deliberate self-harm: a single trauma centre experience.Annals of the Royal College of Surgeons of England · 2026Article
- Suicide risk genes impact evolutionarily conserved survival strategies.Translational psychiatry · 2026Article
- Parental violent offending and offspring suicidal behavior: a nationwide register-based study.Psychological medicine · 2026Article
- Prevalence and clinical correlates of aggressive behavior in male inpatients with alcohol dependence during hospitalization.Frontiers in psychiatry · 2026Article
- Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review.Frontiers in pediatrics · 2026Review
- Suicide Behavior as a Distinct Psychobiology in Major Depression.Advances in experimental medicine and biology · 2026Review
- Suicide risk genes impact evolutionarily conserved survival strategies.Research square · 2025Article
- Defining and assessing international classification of disease suicidality phenotypes for genetic studies.Psychiatry research · 2025Article
- Toxoplasma gondii and suicidal behaviour: discovery, cross-diagnostic confirmation and pathway exploration.Folia parasitologica · 2025Article
- The association between aggression and suicidal behaviors in veterans at risk for suicide.Journal of psychiatric research · 2025Article
112 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 1 country.
Funding
Abstract
Twin, adoption, and family studies have established the heritability of suicide attempts and suicide. Identifying specific suicide diathesis-related genes has proven more difficult. As with psychiatric disorders in general, methodological difficulties include complexity of the phenotype for suicidal behavior and distinguishing suicide diathesis-related genes from genes associated with mood disorders and other suicide-associated psychiatric illness. Adopting an endophenotype approach involving identification of genes associated with heritable intermediate phenotypes, including biological and/or behavioral markers more proximal to genes, is an approach being used for other psychiatric disorders. Therefore, a workshop convened by the American Foundation for Suicide Prevention, the Department of Psychiatry at Columbia University, and the National Institute of Mental Health sought to identify potential target endophenotypes for genetic studies of suicidal behavior. The most promising endophenotypes were trait aggression/impulsivity, early-onset major depression, neurocognitive function, and cortisol social stress response. Other candidate endophenotypes requiring further investigation include serotonergic neurotransmission, second messenger systems, and borderline personality disorder traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.