Trial reportNeurobiology of aging2010
Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex.
Trial report in Neurobiology of aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Impact of Transcranial Direct Current Stimulation on Upper-Limb Motor Performance in Healthy Adults: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2019Pooled it
- tDCS polarity effects in motor and cognitive domains: a meta-analytical review.Experimental brain research · 2012Pooled it
- Self-modulation of motor cortex activity after stroke: a randomized controlled trial.Brain : a journal of neurology · 2022Trial
- Long-Term Application of Cerebellar Transcranial Direct Current Stimulation Does Not Improve Motor Learning in Parkinson's Disease.Cerebellum (London, England) · 2022Trial
- Targeted tDCS Mitigates Dual-Task Costs to Gait and Balance in Older Adults.Annals of neurology · 2021Trial
- Motor Sequence Learning across Multiple Sessions Is Not Facilitated by Targeting Consolidation with Posttraining tDCS in Patients with Progressive Multiple Sclerosis.Neural plasticity · 2021Trial
- Multi-session anodal transcranial direct current stimulation enhances lower extremity functional performance in healthy older adults.Experimental brain research · 2020Trial
- tDCS over left M1 or DLPFC does not improve learning of a bimanual coordination task.Scientific reports · 2016Trial
- Anodal direct current stimulation in the healthy aged: Effects determined by the hemisphere stimulated.Restorative neurology and neuroscience · 2015Trial
- Trial
- Changes in corticomotor excitability and intracortical inhibition of the primary motor cortex forearm area induced by anodal tDCS.PloS one · 2014Trial
- Induction of cortical plasticity and improved motor performance following unilateral and bilateral transcranial direct current stimulation of the primary motor cortex.BMC neuroscience · 2013Trial
- The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- The Influence of Dual Source Cerebellar Transcranial Direct Current Stimulation on Muscle Fatigue.Journal of functional morphology and kinesiology · 2026Article
- Motor Learning in a Complex Motor Task Is Unaffected by Three Consecutive Days of Transcranial Alternating Current Stimulation.Bioengineering (Basel, Switzerland) · 2024Article
- Exploring the use of bimodal transcranial direct current stimulation to enhance movement in individuals with patellofemoral pain-A sham-controlled double blinded pilot study.Frontiers in human neuroscience · 2024Article
- The Influence of Transcranial Alternating Current Stimulation on Fatigue Resistance.Brain sciences · 2023Article
- Optimizing the Effect of tDCS on Motor Sequence Learning in the Elderly.Brain sciences · 2023Article
- Article
- tDCS over the primary motor cortex contralateral to the trained hand enhances cross-limb transfer in older adults.Frontiers in aging neuroscience · 2022Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Healthy ageing is accompanied by limitations in performance of activities of daily living and personal independence. Recent reports demonstrated improvements in motor function induced by noninvasive anodal direct current stimulation (tDCS) of the primary motor cortex (M1) in young healthy adults. Here we tested the hypothesis that a single session of anodal tDCS over left M1 could facilitate performance of right upper extremity tasks required for activities of daily living (Jebsen-Taylor hand function test, JTT) in older subjects relative to Sham in a double-blind cross-over study design. We found (a) significant improvement in JTT function with tDCS relative to Sham that outlasted the stimulation period by at least 30 min, (b) that the older the subjects the more prominent this improvement appeared and (c) that consistent with previous results in younger subjects, these effects were not accompanied by any overt undesired side effect. We conclude that anodal tDCS applied over M1 can facilitate performance of skilled hand functions required for activities of daily living in older subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.