ArticleVaccine2009
HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine.
Article in Vaccine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Human leukocyte antigens and cellular immune responses to anthrax vaccine adsorbed.Infection and immunity · 2013Trial
- An overview of HLA variants in COVID-19 vaccine-induced autoimmunity.International journal of molecular epidemiology and genetics · 2025Review
- Viral vector-based therapeutic HPV vaccines.Clinical and experimental medicine · 2024Review
- Vaccinomics: Paving the Way for Personalized Immunization.Current pharmaceutical design · 2024Review
- Current Challenges in Vaccinology.Frontiers in immunology · 2020Review
- Factors That Influence the Immune Response to Vaccination.Clinical microbiology reviews · 2019Review
- The genetic regulation of infant immune responses to vaccination.Frontiers in immunology · 2015Review
- Article
- Prediction of IL4 inducing peptides.Clinical & developmental immunology · 2013Article
- Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination.PloS one · 2013Article
- Vaccinomics: current findings, challenges and novel approaches for vaccine development.The AAPS journal · 2011Review
- Insights into MHC class I antigen processing gained from large-scale analysis of class I ligands.Cellular and molecular life sciences : CMLS · 2011Review
- Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.PloS one · 2010Article
- SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.Immunogenetics · 2010Article
- Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.Human genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Secreted rubella virus-specific cytokines reflect the immunologic mechanisms underlying adoptive immune responses and are significant markers of immunity to rubella. We studied the association between measures of cellular (cytokine and frequency of cytokine-secreted cells) immune responses and HLA haplotypes (with frequencies of > or =1%) and supertypes among 738 healthy children following two doses of rubella vaccine. Haplotype effects were estimated while accounting for linkage phase ambiguity via an expectation maximization algorithm. Importantly, the majority of HLA class I and class II haplotype associations with different cytokines were consistent between Th1, Th2 and/or innate/proinflammatory cytokine groups. We found few class I supertypes (A1, A2, A3, and B7) with potential associations with IL-10 ELISPOT counts and rubella-specific IL-2, IL-10, TNF-alpha, and IL-6 cytokine secretion levels. Our data indicate that the presence or absence of certain HLA haplotypes and/or supertypes may influence the cytokine immune response to rubella vaccine, and represents a more advanced analysis compared to individual candidate gene association studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.