ArticleBMC systems biology2009
Global transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3.
Article in BMC systems biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 27 citations in OpenAlex.
- Optimization of energy production and central carbon metabolism in a non-respiring eukaryote.Current biology : CB · 2023Article
- StanDep: Capturing transcriptomic variability improves context-specific metabolic models.PLoS computational biology · 2020Article
- Genome-scale modeling of yeast: chronology, applications and critical perspectives.FEMS yeast research · 2017Review
- MIRA: mutual information-based reporter algorithm for metabolic networks.Bioinformatics (Oxford, England) · 2014Article
- Genome-scale modeling enables metabolic engineering of Saccharomyces cerevisiae for succinic acid production.Journal of industrial microbiology & biotechnology · 2013Article
- Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid cell factory.PloS one · 2013Article
- (1)H NMR-based metabolic profiling reveals inherent biological variation in yeast and nematode model systems.Journal of biomolecular NMR · 2011Article
- Shifting the fermentative/oxidative balance in Saccharomyces cerevisiae by transcriptional deregulation of Snf1 via overexpression of the upstream activating kinase Sak1p.Applied and environmental microbiology · 2011Article
- Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes.PLoS computational biology · 2010Article
- Applications of genome-scale metabolic reconstructions.Molecular systems biology · 2009Review
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMitochondrial respiration is an important and widely conserved cellular function in eukaryotic cells. The succinate dehydrogenase complex (Sdhp) plays an important role in respiration as it connects the mitochondrial respiratory chain to the tricarboxylic acid (TCA) cycle where it catalyzes the oxidation of succinate to fumarate. Cellular response to the Sdhp dysfunction (i.e. impaired respiration) thus has important implications not only for biotechnological applications but also for understanding cellular physiology underlying metabolic diseases such as diabetes. We therefore explored the physiological and transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3, that codes for an essential subunit of the Sdhp.
resultsAlthough the Sdhp has no direct role in transcriptional regulation and the flux through the corresponding reaction under the studied conditions is very low, deletion of SDH3 resulted in significant changes in the expression of several genes involved in various cellular processes ranging from metabolism to the cell-cycle. By using various bioinformatics tools we explored the organization of these transcriptional changes in the metabolic and other cellular functional interaction networks.
conclusionOur results show that the transcriptional regulatory response resulting from the impaired respiratory function is linked to several different parts of the metabolism, including fatty acid and sterol metabolism.
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