ArticleInternational journal of experimental pathology2009
Morphological parameters for assessment of burn severity in an acute burn injury rat model.
Article in International journal of experimental pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Indocyanine green dye angiography as an adjunct to assess indeterminate burn wounds: A prospective, multicentered, triple-blinded study.The journal of trauma and acute care surgery · 2019Trial
- Plasma-rich fibrin gel and adipose-derived allogeneic mesenchymal stem cells: innovation in the treatment of second-degree deep burn wound; characterization and in-vivo study.Cell and tissue banking · 2025Article
- Clinical Investigation of a Rapid Non-invasive Multispectral Imaging Device Utilizing an Artificial Intelligence Algorithm for Improved Burn Assessment.Journal of burn care & research : official publication of the American Burn Association · 2023Article
- Triage ofBiomedical optics express · 2023Article
- Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography.Scientific reports · 2022Article
- Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Short-wave infrared light imaging measures tissue moisture and distinguishes superficial from deep burns.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2020Article
- Experimental models of scald burns. A scope review.Acta cirurgica brasileira · 2019Article
- Quantitative long-term measurements of burns in a rat model using Spatial Frequency Domain Imaging (SFDI) and Laser Speckle Imaging (LSI).Lasers in surgery and medicine · 2017Article
- Multimodal evaluation of ultra-short laser pulses treatment for skin burn injuries.Biomedical optics express · 2017Article
- Heterogeneity of mast cells and expression of Annexin A1 protein in a second degree burn model with silver sulfadiazine treatment.PloS one · 2017Article
- Anti-inflammatory and burn injury wound healing properties of the shell of Haliotis diversicolor.BMC complementary and alternative medicine · 2016Article
- Acute discrimination between superficial-partial and deep-partial thickness burns in a preclinical model with laser speckle imaging.Burns : journal of the International Society for Burn Injuries · 2015Article
- Decomposition and entomological colonization of charred bodies - a pilot study.Croatian medical journal · 2013Article
- Evaluation of the effects of honey on acute-phase deep burn wounds.Evidence-based complementary and alternative medicine : eCAM · 2013Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determination of burn severity (i.e. burn depth) is important for effective medical management and treatment. Using a recently described acute burn model, we studied various morphological parameters to detect burn severity. Anaesthetized Sprague-Dawley rats received burns of various severity (0- to 14-s contact time) followed by standard resuscitation using intravenous fluids. Biopsies were taken from each site after 5 h, tissues fixed in 10% neutral-buffered formalin, processed and stained with haematoxylin and eosin. Superficial burn changes in the epidermis included early keratinocyte swelling progressing to epidermal thinning and nuclear elongation in deeper burns. Subepidermal vesicle formation generally decreased with deeper burns and typically contained grey foamy fluid. Dermal burns were typified by hyalinized collagen and a lack of detectable individual collagen fibres on a background of grey to pale eosinophilic seroproteinaceous fluid. Intact vascular structures were identified principally deep to the burn area in the collagen. Follicle cell injury was identified by cytoplasmic clearing/swelling and nuclear pyknosis, and these follicular changes were often the deepest evidence of burn injury seen for each time point. Histological scores (epidermal changes) or dermal parameter depths (dermal changes) were regressed on burn contact time. Collagen alteration (r(2) = 0.91) correlated best to burn severity followed by vascular patency (r(2) = 0.82), epidermal changes (r(2) = 0.76), subepidermal vesicle formation (r(2) = 0.74) and follicular cell injury was useful in all but deep burns. This study confirms key morphological parameters can be an important tool for the detection of burn severity in this acute burn model.
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