ArticleThe European journal of neuroscience2009
A common gene exclusion mechanism used by two chemosensory systems.
Article in The European journal of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Chemosensory Receptors in Vertebrates: Structure and Computational Modeling Insights.International journal of molecular sciences · 2025Review
- Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.Science advances · 2022Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ.Frontiers in neuroanatomy · 2014Article
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- Non-exclusive exclusion (Commentary on Capello et al.).The European journal of neuroscience · 2009Article
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5 authors at 2 institutions in 2 countries.
Funding
Abstract
Sensory coding strategies within vertebrates involve the expression of a limited number of receptor types per sensory cell. In mice, each vomeronasal sensory neuron transcribes monoallelically a single V1R pheromone receptor gene, chosen from a large V1R repertoire. The nature of the signals leading to this strict receptor expression is unknown, but is apparently based on a negative feedback mechanism initiated by the transcription of the first randomly chosen functional V1R gene. We show, in vivo, that the genetic replacement of the V1rb2 pheromone receptor coding sequence by an unrelated one from the odorant receptor gene M71 maintains gene exclusion. The expression of this exogenous odorant receptor in vomeronasal neurons does not trigger the transcription of odorant receptor-associated signalling molecules. These results strongly suggest that despite the different odorant and vomeronasal receptor expression sites, function and transduction cascades, a common mechanism is used by these chemoreceptors to regulate their transcription.
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