ReviewCurrent molecular medicine2009
The contribution of gammadelta T cells to the pathogenesis of EAE and MS.
Review in Current molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- The Plasticity of Immune Cell Response Complicates Dissecting the Underlying Pathology of Multiple Sclerosis.Journal of immunology research · 2024Review
- γδ T cells: origin and fate, subsets, diseases and immunotherapy.Signal transduction and targeted therapy · 2023Review
- γδ T Lymphocytes as a Double-Edged Sword-State of the Art in Gynecological Diseases.International journal of molecular sciences · 2022Review
- Connecting Neuroinflammation and Neurodegeneration in Multiple Sclerosis: Are Oligodendrocyte Precursor Cells a Nexus of Disease?Frontiers in cellular neuroscience · 2021Review
- Article
- γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice.Journal of neuroinflammation · 2017Article
- Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.Scientific reports · 2017Article
- High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis.Frontiers in immunology · 2017Article
- The Emerging Roles of Gamma-Delta T Cells in Tissue Inflammation in Experimental Autoimmune Encephalomyelitis.Frontiers in immunology · 2016Review
- Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis.Journal of neuroinflammation · 2015Article
- Article
- Article
- γδ T cells as a major source of IL-17 production during age-dependent RPE degeneration.Investigative ophthalmology & visual science · 2014Article
- Innate immunity drives xenobiotic-induced murine autoimmune cholangitis.Clinical and experimental immunology · 2014Article
- γδ T cell subsets play opposing roles in regulating experimental autoimmune encephalomyelitis.Cellular immunology · 2014Article
- Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The innate immune system in demyelinating disease.Immunological reviews · 2012Review
- Target specificity of an autoreactive pathogenic human γδ-T cell receptor in myositis.The Journal of biological chemistry · 2012Article
- Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers.Immunologic research · 2012Review
- Inflammation and adaptive immunity in Parkinson's disease.Cold Spring Harbor perspectives in medicine · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Gammadelta T cells are a multifaceted group of cells which have both innate and adaptive characteristics and functions. Although they are most commonly known for their response to mycobacterium and their locations at mucosal sites, their roles in autoimmunity are still unclear. gammadelta T cells have been seen in the CSF and lesions of Multiple Sclerosis patients and although their function is not entirely understood, it is clear these cells may have roles in regulating autoimmune inflammation in the CNS. Recent studies have focused on the role of gammadelta T cells in MS and EAE as both pathogenic and protective, their functions within the CNS, the types of subsets and a possible role in Th17 inflammation. In this review we will examine the data acquired from both human patients and the murine models of MS, experimental autoimmune encephalomyelitis (EAE), in order to gain a clear picture of how gammadelta T cells influence pathogenesis of EAE and MS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.