ArticleJournal of the American Chemical Society2009
Protein nanoparticles engineered to sense kinase activity in MRI.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 85 citations in OpenAlex.
- A programmable genetic platform for engineering noninvasive biosensors.Science advances · 2026Article
- A programmable genetic platform for engineering noninvasive biosensors.bioRxiv : the preprint server for biology · 2025Article
- The role of responsive MRI probes in the past and the future of molecular imaging.Chemical science · 2024Review
- Rational design of a genetically encoded NMR zinc sensor.Chemical science · 2023Article
- Designing Protein-Based Probes for Sensing Biological Analytes with Magnetic Resonance Imaging.Analysis & sensing · 2022Article
- Article
- Multifield and inverse-contrast switching of magnetocaloric high contrast ratio MRI labels.Magnetic resonance in medicine · 2021Article
- Molecular Imaging of Deoxycytidine Kinase Activity Using Deoxycytidine-Enhanced CEST MRI.Cancer research · 2019Article
- Recent Advances in Protein Kinase Activity Analysis Based on Nanomaterials.International journal of molecular sciences · 2019Review
- Ferritin-based drug delivery systems: Hybrid nanocarriers for vascular immunotargeting.Journal of controlled release : official journal of the Controlled Release Society · 2018Review
- Acoustically modulated magnetic resonance imaging of gas-filled protein nanostructures.Nature materials · 2018Article
- Biomolecular MRI reporters: Evolution of new mechanisms.Progress in nuclear magnetic resonance spectroscopy · 2017Review
- Non-invasive imaging using reporter genes altering cellular water permeability.Nature communications · 2016Article
- Molecular fMRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Engineering intracellular biomineralization and biosensing by a magnetic protein.Nature communications · 2015Article
- Molecular engineering of nonmetallic biosensors for CEST MRI.ACS chemical biology · 2015Article
- Advances in using MRI probes and sensors for in vivo cell tracking as applied to regenerative medicine.Disease models & mechanisms · 2015Review
- Detecting enzyme activities with exogenous MRI contrast agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014Review
- Why and how we determine nephron number.Pediatric nephrology (Berlin, Germany) · 2014Review
- Genetic tools to manipulate MRI contrast.NMR in biomedicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We introduce a family of protein nanoparticles capable of sensing analytes in conjunction with magnetic resonance imaging (MRI). The new sensors are derived from the iron storage protein ferritin (Ft); they are designed and optimized using facile protein engineering methods, and self-assembled in cells harboring specific combinations of DNA coding sequences. As illustration, we show that suitably constructed Ft-based sensors can report activity of the important neural signaling enzyme protein kinase A (PKA). Phosphorylation of the engineered Ft-based nanoparticles by PKA promotes clustering and changes in T(2)-weighted MRI signal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.