Trial reportJournal of neurosurgery2009
Intraoperative magnesium infusion during carotid endarterectomy: a double-blind placebo-controlled trial.
Trial report in Journal of neurosurgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. It is linked to trial NCT03558516 (The Effect of Magnesium Sulphate on Intraoperative Blood Loss in Meningioma Patient Undergoing Craniotomy With Tumor Removal), which is not on this map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Magnesium Sulphate on Intraoperative Blood Loss in Meningioma Patient Undergoing Craniotomy With Tumor Removal
Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Methodology of the Field Administration of Stroke Therapy - Magnesium (FAST-MAG) phase 3 trial: Part 1 - rationale and general methods.International journal of stroke : official journal of the International Stroke Society · 2014Trial
- Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.Stroke · 2013Trial
- A pilot study of darbepoetin alfa for prophylactic neuroprotection in aortic surgery.Neurocritical care · 2013Trial
- Intranasal Insulin Administration to Prevent Delayed Neurocognitive Recovery and Postoperative Neurocognitive Disorder: A Narrative Review.International journal of environmental research and public health · 2021Review
- Neuroprotection against stroke and encephalopathy after cardiac surgery.Interventional medicine & applied science · 2019Review
- Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.Neuropsychiatric disease and treatment · 2018Article
- Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation.British journal of pharmacology · 2017Article
- Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium.BMC neurology · 2016Article
- Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly.Anesthesiology clinics · 2015Review
- Magnesium: potential roles in neurovascular disease.Frontiers in neurology · 2014Review
- Article
- Is there a place for cerebral preconditioning in the clinic?Translational stroke research · 2010Article
- Review
Corrections and comments
- Expression of concern
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
objectRecent data from both experimental and clinical studies have supported the use of intravenous magnesium as a potential therapy in the setting of cerebral ischemia. This study assessed whether intraoperative magnesium therapy improves neuropsychometric testing (NPT) following carotid endarterectomy (CEA).
methodsOne hundred eight patients undergoing CEA were randomly assigned to receive placebo infusion or 1 of 3 magnesium-dosing protocols. Neuropsychometric testing was performed 1 day after surgery and compared with baseline performance. Assessment was also performed on a set of 35 patients concurrently undergoing lumbar laminectomy to serve as a control group for NPT. A forward stepwise logistic regression analysis was performed to evaluate the impact of magnesium therapy on NPT. A subgroup analysis was then performed, analyzing the impact of each intraoperative dose on NPT.
resultsPatients treated with intravenous magnesium infusion demonstrated less postoperative neurocognitive impairment than those treated with placebo (OR 0.27, 95% CI 0.10-0.74, p = 0.01). When stratified according to dosing bolus and intraoperative magnesium level, those who were treated with low-dose magnesium had less cognitive decline than those treated with placebo (OR 0.09, 95% CI 0.02-0.50, p < 0.01). Those in the high-dose magnesium group demonstrated no difference from the placebo-treated group.
conclusionsLow-dose intraoperative magnesium therapy protects against neurocognitive decline following CEA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.