ArticleCancer causes & control : CCC2009
Maternal exposure to medical radiation and Wilms tumor in the offspring: a report from the Children's Oncology Group.
Article in Cancer causes & control : CCC, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- The influence of environmental exposures during the preconception period on offspring outcomes: a systematic review.Frontiers in public health · 2025Pooled it
- Early life ionizing radiation exposure and cancer risks: systematic review and meta-analysis.Pediatric radiology · 2021Pooled it
- Environmental risk factors of Wilms tumour: A systematic review and meta-analysis.EJC paediatric oncology · 2024Review
- Cancer risks among studies of medical diagnostic radiation exposure in early life without quantitative estimates of dose.The Science of the total environment · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveThis study examined the association between pre-conception and in utero maternal medical radiation exposure and Wilms tumor, using data from a large population-based case-control study.
methodsCases were identified from the National Wilms Tumor Study Group. Controls were identified by random digit dialing and frequency matched to child's age and geographic area of residence in the United States and Canada. Interview data from 512 cases and 509 controls were analyzed using multivariable logistic regression. Odds ratios (OR) and 95% confidence intervals (CI) for Wilms tumor and exposure to: (1) maternal X-ray alone and; (2) all medical radiation types (X-ray, CT, RT, Nuclear scans, Fluoroscopy) combined, for the period from two years before conception until child birth were estimated after adjustment for age, geographic area, maternal education, and household income.
resultsWe found no consistent association between the risk of Wilms tumor and either maternal X-ray exposure (OR 0.9, 95% CI 0.7-1.3) or all medical radiation types combined (OR 0.9, 95% CI 0.7-1.2). No meaningful associations were seen for analysis of gonadal or non-gonadal radiation exposure.
conclusionOur study did not find any consistent pattern of association between Wilms tumor and maternal radiation exposure during pre-pregnancy or pregnancy period. In view of the negative findings from the largest case control study of this question to date, the reduced doses of biological radiation during pregnancy, and the requirements for an improved study design, we believe that future studies of this exposure may not be a priority for research on Wilms tumor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.