ReviewImmunologic research2009
Understanding the focused CD4 T cell response to antigen and pathogenic organisms.
Review in Immunologic research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Computational Evolution Protocol for Peptide Design.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections.Frontiers in immunology · 2019Article
- Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus.Frontiers in immunology · 2019Article
- β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells.American journal of respiratory cell and molecular biology · 2018Article
- Population mechanics: A mathematical framework to study T cell homeostasis.Scientific reports · 2017Article
- Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads.Biotechnology and bioengineering · 2015Article
- The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance.Royal Society open science · 2015Article
- Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate.Cellular and molecular life sciences : CMLS · 2014Article
- Article
- The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings.Frontiers in immunology · 2013Review
- Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal.Frontiers in immunology · 2013Review
- CD4 T-cell memory responses to viral infections of humans show pronounced immunodominance independent of duration or viral persistence.Journal of virology · 2013Article
- Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host.Immunology · 2012Article
- Spectrum of HLA associations: the case of medically refractory pediatric acute lymphoblastic leukemia.Immunogenetics · 2012Article
- Flanking residues are central to DO11.10 T cell hybridoma stimulation by ovalbumin 323-339.PloS one · 2012Article
- Immune System as a Sensory System.International journal of biomedical science : IJBS · 2010Article
- Immunology at the university of Rochester.Immunologic research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Immunodominance is a term that reflects the final, very limited peptide specificity of T cells that are elicited during an immune response. Recent experiments in our laboratory compel us to propose a new paradigm for the control of immunodominance in CD4 T cell responses, stating that immunodominance is peptide-intrinsic and is dictated by the off-rate of peptides from MHC class II molecules. Our studies have revealed that persistence of peptide:class II complexes both predicts and controls CD4 T cell immunodominance and that this parameter can be rationally manipulated to either promote or eliminate immune responses. Mechanistically, we have determined that DM editing in APC is a key event that is influenced by the kinetic stability of class II:peptide complexes and that differential persistence of complexes also impacts the expansion phase of the immune response. These studies have important implications for rational vaccine design and for understanding the immunological mechanisms that limit the specificity of CD4 T cell responses.
Indexed as
Identifiers
19198764What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.