ArticlePloS one2009
Evidence for variation in the effective population size of animal mitochondrial DNA.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
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- Mitochondrial sequence variants: testing imputation accuracy and their association with dairy cattle milk traits.Genetics, selection, evolution : GSE · 2024Article
- Previously unmeasured genetic diversity explains part of Lewontin's paradox in abioRxiv : the preprint server for biology · 2024Article
- The completed mitochondrial genomes of Globodera vulgaris reveals new insights into the genus Globodera phylogeny.Scientific reports · 2024Article
- Mitochondrial genome plasticity of mammalian species.BMC genomics · 2024Article
- The effects of mutation and recombination rate heterogeneity on the inference of demography and the distribution of fitness effects.bioRxiv : the preprint server for biology · 2023Article
- Genetic diversity varies with species traits and latitude in predatory soil arthropods (Myriapoda: Chilopoda).Global ecology and biogeography : a journal of macroecology · 2023Article
- Uniparental Inheritance and Recombination as Strategies to Avoid Competition and Combat Muller's Ratchet among Mitochondria in Natural Populations of the FungusJournal of fungi (Basel, Switzerland) · 2023Article
- The genome of the Pyrenean desman and the effects of bottlenecks and inbreeding on the genomic landscape of an endangered species.Evolutionary applications · 2021Article
- Mitochondrial DNA Sequence Diversity in Mammals: A Correlation between the Effective and Census Population Sizes.Genome biology and evolution · 2020Article
- Superoxide dismutase 1 is positively selected to minimize protein aggregation in great apes.Cellular and molecular life sciences : CMLS · 2017Article
- Contrasting Rates of Molecular Evolution and Patterns of Selection among Gymnosperms and Flowering Plants.Molecular biology and evolution · 2017Article
- Extreme Mitogenomic Variation in Natural Populations of Chaetognaths.Genome biology and evolution · 2017Article
- DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA.Heredity · 2017Article
- Molecular Evolutionary Consequences of Island Colonization.Genome biology and evolution · 2016Article
- Determinants of genetic diversity.Nature reviews. Genetics · 2016Review
- Adaptive Evolution Is Substantially Impeded by Hill-Robertson Interference in Drosophila.Molecular biology and evolution · 2016Article
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2 authors.
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Abstract
backgroundIt has recently been shown that levels of diversity in mitochondrial DNA are remarkably constant across animals of diverse census population sizes and ecologies, which has led to the suggestion that the effective population of mitochondrial DNA may be relatively constant.
resultsHere we present several lines of evidence that suggest, to the contrary, that the effective population size of mtDNA does vary, and that the variation can be substantial. First, we show that levels of mitochondrial and nuclear diversity are correlated within all groups of animals we surveyed. Second, we show that the effectiveness of selection on non-synonymous mutations, as measured by the ratio of the numbers of non-synonymous and synonymous polymorphisms, is negatively correlated to levels of mitochondrial diversity. Finally, we estimate the effective population size of mitochondrial DNA in selected mammalian groups and show that it varies by at least an order of magnitude.
conclusionsWe conclude that there is variation in the effective population size of mitochondria. Furthermore we suggest that the relative constancy of DNA diversity may be due to a negative correlation between the effective population size and the mutation rate per generation.
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