ArticlePloS one2009
High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Natural Resistance to HIV Infection: Role of Immune Activation.Immunity, inflammation and disease · 2025Review
- Reconstitution of Peripheral T Cells by Tissue-Derived CCR4+ Central Memory Cells Following HIV-1 Antiretroviral Therapy.Pathogens & immunity · 2016Article
- TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.PLoS pathogens · 2016Article
- Neurocognitive decline in HIV patients is associated with ongoing T-cell activation in the cerebrospinal fluid.Annals of clinical and translational neurology · 2015Article
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- Long-term persistence of limited HTLV-I Tax-specific cytotoxic T cell clones in a patient with adult T cell leukemia/lymphoma after allogeneic stem cell transplantation.Journal of clinical immunology · 2012Article
- Severe pandemic H1N1 2009 infection is associated with transient NK and T deficiency and aberrant CD8 responses.PloS one · 2012Article
- Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children.PloS one · 2012Article
- Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study.Journal of the International AIDS Society · 2011Article
- HIV-1 infection abrogates CD8+ T cell mitogen-activated protein kinase signaling responses.Journal of virology · 2011Article
- Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection.Journal of virology · 2011Article
- Age-related deregulation of naive T cell homeostasis in elderly humans.Age (Dordrecht, Netherlands) · 2011Article
- Influenza A H5N1 and HIV co-infection: case report.BMC infectious diseases · 2010Article
- HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model.Mucosal immunology · 2010Article
- Characterization of T-cell responses in macaques immunized with a single dose of HIV DNA vaccine.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe relationship of elevated T cell activation to altered T cell differentiation profiles, each defining features of HIV-1 infection, has not been extensively explored. We hypothesized that anti-retroviral suppression of T cell activation levels would lead to alterations in the T cell differentiation of total and HIV-1 specific CD8+ T cell responses among recently HIV-1 infected adults. METHODOLOGY/PRINCIPAL
findingsWe performed a longitudinal study simultaneously measuring T cell activation and maturation markers on both total and antigen-specific T cells in recently infected adults: prior to treatment; after the initiation of HAART; and after treatment was halted. Prior to treatment, HIV-1 Gag-specific CD8+ T cells were predominantly of a highly activated, intermediate memory (CD27+CD28-) phenotype, while CMV pp65-specific CD8+ T cells showed a late memory (CD27-CD28-), low activation phenotype. Participants with the highest fraction of late memory (CD27-CD28-) HIV-1-specific CD8+ T cells had higher CD4+ T cell counts (rho = +0.74, p = 0.004). In turn, those with the highest fraction of intermediate memory (CD27+ CD28-) HIV-1 specific CD8+ T cells had high total CD8+ T cell activation (rho = +0.68, p = 0.01), indicating poorer long-term clinical outcomes. The HIV-1 specific T cell differentiation profile was not readily altered by suppression of T cell activation following HAART treatment. CONCLUSIONS/SIGNIFICANCE: A more differentiated, less activated HIV-1 specific CD8+ T cell response may be clinically protective. Anti-retroviral treatment initiated two to four months after infection lowered T cell activation but had no effect on the differentiation profile of the HIV-1-specific response. Intervention during the first month of acute infection may be required to shift the differentiation phenotype of HIV-1 specific responses to a more clinically favorable profile.
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