ArticlePloS one2009
Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 118 citations in OpenAlex.
- Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy.Molecules (Basel, Switzerland) · 2023Review
- Macrophage-targeted nanoparticles mediate synergistic photodynamic therapy and immunotherapy of tuberculosis.RSC advances · 2023Article
- SOX2Mediates Carbon Nanotube-Induced Fibrogenesis and Fibroblast Stem Cell Acquisition.ACS biomaterials science & engineering · 2020Article
- Cellular Toxicity and Immunological Effects of Carbon-based Nanomaterials.Particle and fibre toxicology · 2019Review
- Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Nanoparticle Wettability Influences Nanoparticle-Phospholipid Interactions.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Review
- Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy.Frontiers in oncology · 2018Review
- Mediation of the single-walled carbon nanotubes induced pulmonary fibrogenic response by osteopontin and TGF-β1.Experimental lung research · 2017Article
- Article
- Defect-Induced Near-Infrared Photoluminescence of Single-Walled Carbon Nanotubes Treated with Polyunsaturated Fatty Acids.Journal of the American Chemical Society · 2017Article
- Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids.Biochemical and biophysical research communications · 2017Review
- Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells.Nanotoxicology · 2016Article
- Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications.Toxicology and applied pharmacology · 2016Review
- "Eat me" imaging and therapy.Advanced drug delivery reviews · 2016Review
- Silica coating influences the corona and biokinetics of cerium oxide nanoparticles.Particle and fibre toxicology · 2015Article
- Static and Dynamic Microscopy of the Chemical Stability and Aggregation State of Silver Nanowires in Components of Murine Pulmonary Surfactant.Environmental science & technology · 2015Article
- The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response.Memorias do Instituto Oswaldo Cruz · 2015Article
- Inhalation of silver nanomaterials--seeing the risks.International journal of molecular sciences · 2014Review
- Lung macrophages "digest" carbon nanotubes using a superoxide/peroxynitrite oxidative pathway.ACS nano · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
Abstract
Broad applications of single-walled carbon nanotubes (SWCNT) dictate the necessity to better understand their health effects. Poor recognition of non-functionalized SWCNT by phagocytes is prohibitive towards controlling their biological action. We report that SWCNT coating with a phospholipid "eat-me" signal, phosphatidylserine (PS), makes them recognizable in vitro by different phagocytic cells - murine RAW264.7 macrophages, primary monocyte-derived human macrophages, dendritic cells, and rat brain microglia. Macrophage uptake of PS-coated nanotubes was suppressed by the PS-binding protein, Annexin V, and endocytosis inhibitors, and changed the pattern of pro- and anti-inflammatory cytokine secretion. Loading of PS-coated SWCNT with pro-apoptotic cargo (cytochrome c) allowed for the targeted killing of RAW264.7 macrophages. In vivo aspiration of PS-coated SWCNT stimulated their uptake by lung alveolar macrophages in mice. Thus, PS-coating can be utilized for targeted delivery of SWCNT with specified cargoes into professional phagocytes, hence for therapeutic regulation of specific populations of immune-competent cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.