ArticleNature neuroscience2009
Slow glycinergic transmission mediated by transmitter pooling.
Article in Nature neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 42 citations in OpenAlex.
- Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex.ACS chemical neuroscience · 2024Article
- Spatiotemporal Control of Noradrenaline-Dependent Synaptic Transmission in Mouse Dorsal Raphe Serotonin Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Principal Neurons in the Anteroventral Cochlear Nucleus Express Cell-Type Specific Glycine Receptor α Subunits.Neuroscience · 2019Article
- Cytokine inflammatory threat, but not LPS one, shortens GABAergic synaptic currents in the mouse spinal cord organotypic cultures.Journal of neuroinflammation · 2019Article
- Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses.The Journal of physiology · 2017Article
- Developmental Shift of Inhibitory Transmitter Content at a Central Auditory Synapse.Frontiers in cellular neuroscience · 2017Article
- Auditory Golgi cells are interconnected predominantly by electrical synapses.Journal of neurophysiology · 2016Article
- Altered development in GABA co-release shapes glycinergic synaptic currents in cultured spinal slices of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.The Journal of physiology · 2016Article
- Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons.The Journal of physiology · 2016Article
- Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Neural Circuits: Introducing Different Scales of Temporal Processing.Current biology : CB · 2015Article
- Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Inhibitory properties underlying non-monotonic input-output relationship in low-frequency spherical bushy neurons of the gerbil.Frontiers in neural circuits · 2015Article
- Dynamic fidelity control to the central auditory system: synergistic glycine/GABAergic inhibition in the cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Differential GABAergic and glycinergic inputs of inhibitory interneurons and Purkinje cells to principal cells of the cerebellar nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Sex differences in corticotropin-releasing factor receptor-1 action within the dorsal raphe nucleus in stress responsivity.Biological psychiatry · 2014Article
- The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Activity-dependent modulation of inhibitory synaptic kinetics in the cochlear nucleus.Frontiers in neural circuits · 2014Article
- Target-specific IPSC kinetics promote temporal processing in auditory parallel pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Most fast-acting neurotransmitters are rapidly cleared from synaptic regions. This feature isolates synaptic sites, rendering the time course of synaptic responses independent of the number of active synapses. We found an exception at glycinergic synapses on granule cells of the rat dorsal cochlear nucleus. Here the duration of inhibitory postsynaptic currents (IPSCs) was dependent on the number of presynaptic axons that were stimulated and on the number of vesicles that were released from each axon. Increasing the stimulus number or frequency, or blocking glycine uptake, slowed synaptic decays, whereas a low-affinity competitive antagonist of glycine receptors (GlyRs) accelerated IPSC decay. These effects could be explained by unique features of GlyRs that are activated by pooling of glycine across synapses. Functionally, increasing the number of IPSPs markedly lengthened the period of spike inhibition following the cessation of presynaptic stimulation. Thus, temporal properties of inhibition can be controlled by activity levels in multiple presynaptic cells or by adjusting release probability at individual synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.