ArticleNature methods2009
Direct determination of haplotypes from single DNA molecules.
Article in Nature methods, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus.Frontiers in immunology · 2026Article
- Single-Molecule Nanomechanical Genotyping with DNA Origami-Based Shape IDs.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique.Journal of human genetics · 2022Article
- Customized optical mapping by CRISPR-Cas9 mediated DNA labeling with multiple sgRNAs.Nucleic acids research · 2021Article
- Programming DNA origami assembly for shape-resolved nanomechanical imaging labels.Nature protocols · 2018Article
- Recent Advances in Experimental Whole Genome Haplotyping Methods.International journal of molecular sciences · 2017Review
- Sub-100-nm metafluorophores with digitally tunable optical properties self-assembled from DNA.Science advances · 2017Article
- DNA origami-based shape IDs for single-molecule nanomechanical genotyping.Nature communications · 2017Article
- Chromosome-Range Whole-Genome High-Throughput Experimental Haplotyping by Single-Chromosome Microdissection.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Haplotype-resolved genome sequencing: experimental methods and applications.Nature reviews. Genetics · 2015Review
- Complete genome phasing of family quartet by combination of genetic, physical and population-based phasing analysis.PloS one · 2013Article
- Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA.Nature chemistry · 2012Article
- Massively parallel haplotyping on microscopic beads for the high-throughput phase analysis of single molecules.PloS one · 2012Article
- Gold nanoparticles for high-throughput genotyping of long-range haplotypes.Nature nanotechnology · 2011Article
- Genome structural variation discovery and genotyping.Nature reviews. Genetics · 2011Review
- Completely phased genome sequencing through chromosome sorting.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Whole-genome molecular haplotyping of single cells.Nature biotechnology · 2011Article
- Enhancing single molecule imaging in optofluidics and microfluidics.International journal of molecular sciences · 2011Review
- Allele-specific DNA methylation: beyond imprinting.Human molecular genetics · 2010Review
- Experimental generation of SNP haplotype signatures in patients with sickle cell anaemia.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Determining the long-range haplotypes in a diploid individual is a major technical challenge. Here we report a method of molecular haplotyping by directly imaging multiple polymorphic sites on individual human DNA molecules simultaneously. We demonstrate the utility of this technology by accurately determining the haplotypes consisting of up to 16 single-nucleotide polymorphisms in genomic regions up to 50 kilobases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.