Evidence map›Paper›PMID 19197806›Full record

ReviewSeminars in reproductive medicine2009

The role of growth factors and cytokines during implantation: endocrine and paracrine interactions.

Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Hugh S Taylor

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in reproductive medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04547699 (Impact of Cytokine Supplementation With Various Protein Concentrations Into Human in Vitro Culture Medium on ICSI Cycle Outcome), which is not on this map. Cited by 120 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 5 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04547699 nacompletednot on this mapstarted 2020, after this paper: background citation

Impact of Cytokine Supplementation With Various Protein Concentrations Into Human in Vitro Culture Medium on ICSI Cycle Outcome

TypeinterventionalSponsorMansoura Integrated Fertility CenterRan2020 to 2022Enrolled700ConditionsICSIArmsA single step culture medium
3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 5 syntheses or guidelines pooled it, 316 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Development of placental abnormalities in location and anatomy.Acta obstetricia et gynecologica Scandinavica · 2020
    Pooled it
  6. Trial
  7. Review
  8. Observational
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Implantation Failure: Where to Look Up?Journal of clinical medicine · 2025
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ozlem Guzeloglu-KayisliDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
Umit Ali Kayisli
Hugh S Taylor
Yale University · US

Funding

Tissue Factor and EmdometriosisU54HD052668 · NICHD · YALE UNIVERSITY · PI KLIMAN, HARVEY J · 2007 to 2011
$6.6M
HOX Gene Expression by Endocrine Disrupting ChemicalsR01ES010610 · NIEHS · YALE UNIVERSITY · PI TAYLOR, HUGH SMITH · 2001 to 2011
$2.9M
NICHD NIH HHS U54 HD052668NIEHS NIH HHS R01 ES010610
6 · The paper itself

Abstract

Implantation, a critical step for establishing pregnancy, requires molecular and cellular events resulting in uterine growth and differentiation, blastocyst adhesion, invasion, and placental formation. Successful implantation requires a receptive endometrium, a normal and functional embryo at the blastocyst stage, and a synchronized dialogue between maternal and embryonic tissues. In addition to the well-characterized role of sex steroids, the complexity of embryo implantation and placentation is exemplified by the number of cytokines and growth factors with demonstrated roles in these processes. Disturbances in the normal expression and action of these cytokines result in an absolute or partial failure of implantation and abnormal placental formation in mice and human. Members of the gp130 cytokine family, interleukin-11 (IL-11) and leukemia inhibitory factor, the transforming growth factor beta superfamily, the colony-stimulating factors, and the IL-1 and IL-15 systems are crucial molecules for a successful implantation. Chemokines are also important, both in recruiting specific cohorts of leukocytes to the implantation site and in trophoblast trafficking and differentiation. This review provides discussion of the embryonic and uterine factors that are involved in the process of implantation in autocrine, paracrine, and/or juxtacrine manners at the hormonal, cellular, and molecular levels.

Indexed as

AnimalsCytokinesEmbryo ImplantationEmbryonic DevelopmentEndocrine CellsFemaleHumansIntercellular Signaling Peptides and ProteinsModels, BiologicalParacrine CommunicationPregnancyTranscription FactorsCytokinesIntercellular Signaling Peptides and ProteinsTranscription Factors

Identifiers

PMID19197806
PMCPMC3107839
OpenAlexW1996814033

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.