ArticlePLoS computational biology2009
Evidence for gene-specific rather than transcription rate-dependent histone H3 exchange in yeast coding regions.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Spt5 orchestrates cryptic transcript suppression and transcriptional directionality.Communications biology · 2024Article
- Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast.Nature communications · 2018Article
- Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus.Molecular and cellular biology · 2016Article
- Global target mRNA specification and regulation by the RNA-binding protein ZFP36.Genome biology · 2014Article
- Genome-wide mapping of yeast histone chaperone anti-silencing function 1 reveals its role in condensin binding with chromatin.PloS one · 2014Article
- Gene promoters dictate histone occupancy within genes.The EMBO journal · 2013Article
- Progressive methylation of ageing histones by Dot1 functions as a timer.EMBO reports · 2011Article
- Patterns and mechanisms of ancestral histone protein inheritance in budding yeast.PLoS biology · 2011Article
- Control of chromatin structure by spt6: different consequences in coding and regulatory regions.Molecular and cellular biology · 2011Article
- Analysis of biological features associated with meiotic recombination hot and cold spots in Saccharomyces cerevisiae.PloS one · 2011Article
- Histone exchange and histone modifications during transcription and aging.Biochimica et biophysica actaReview
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Authors and funding
2 authors.
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Abstract
In eukaryotic organisms, histones are dynamically exchanged independently of DNA replication. Recent reports show that different coding regions differ in their amount of replication-independent histone H3 exchange. The current paradigm is that this histone exchange variability among coding regions is a consequence of transcription rate. Here we put forward the idea that this variability might be also modulated in a gene-specific manner independently of transcription rate. To that end, we study transcription rate-independent replication-independent coding region histone H3 exchange. We term such events relative exchange. Our genome-wide analysis shows conclusively that in yeast, relative exchange is a novel consistent feature of coding regions. Outside of replication, each coding region has a characteristic pattern of histone H3 exchange that is either higher or lower than what was expected by its RNAPII transcription rate alone. Histone H3 exchange in coding regions might be a way to add or remove certain histone modifications that are important for transcription elongation. Therefore, our results that gene-specific coding region histone H3 exchange is decoupled from transcription rate might hint at a new epigenetic mechanism of transcription regulation.
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