ArticleObesity (Silver Spring, Md.)2009
Obesity attenuates the contribution of African admixture to the insulin secretory profile in peripubertal children: a longitudinal analysis.
Article in Obesity (Silver Spring, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Exercise reduces body fat and improves insulin sensitivity and pancreatic β-cell function in overweight and obese male Taiwanese adolescents.BMC pediatrics · 2018Trial
- Prediabetes in youth - mechanisms and biomarkers.The Lancet. Child & adolescent health · 2017Article
- Insulin secretion abnormalities in exocrine pancreatic sufficient cystic fibrosis patients.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2015Article
- Genetic admixture and obesity: recent perspectives and future applications.Human heredity · 2013Review
- Biogeographic ancestry, self-identified race, and admixture-phenotype associations in the Heart SCORE Study.American journal of epidemiology · 2012Article
- Racial/ethnic and sex differences in the ability of metabolic syndrome criteria to predict elevations in fasting insulin levels in adolescents.The Journal of pediatrics · 2011Article
- Beyond thriftiness: independent and interactive effects of genetic and dietary factors on variations in fat deposition and distribution across populations.American journal of physical anthropology · 2011Article
- Etiology, Treatment and Prevention of Obesity in Childhood and Adolescence: A Decade in Review.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2011Article
- Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children.Human genomics · 2011Article
- Adiposity and β-cell function: relationships differ with ethnicity and age.Obesity (Silver Spring, Md.) · 2010Article
- A conserved role for syndecan family members in the regulation of whole-body energy metabolism.PloS one · 2010Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The pubertal transition has been identified as a time of risk for development of type 2 diabetes, particularly among vulnerable groups, such as African Americans (AAs). Documented ethnic differences in insulin secretory dynamics may predispose overweight AA adolescents to risk for type 2 diabetes. The objectives of this longitudinal study were to quantify insulin secretion and clearance in a cohort of 90 AA and European American (EA) children over the pubertal transition and to explore the association of genetic factors and adiposity with repeated measures of insulin secretion and clearance during this critical period. Insulin sensitivity was determined by intravenous glucose tolerance test (IVGTT) and minimal modeling; insulin secretion and clearance by C-peptide modeling; genetic ancestry by admixture analysis. Mixed-model longitudinal analysis indicated that African genetic admixture (AfADM) was independently and positively associated with first-phase insulin secretion within the entire group (P < 0.001), and among lean children (P < 0.01). When examined within pubertal stage, this relationship became significant at Tanner stage 3. Total body fat was a significant determinant of first-phase insulin secretion overall and among obese children (P < 0.001). Total body fat, but not AfADM, was associated with insulin clearance (P < 0.001). In conclusion, genetic factors, as reflected in AfADM, may explain greater first-phase insulin secretion among peripubertal AA vs. EA; however, the influence of genetic factors is superseded by adiposity. The pubertal transition may affect the development of the beta-cell response to glucose in a manner that differs with ethnic/genetic background.
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