ArticleAmerican journal of public health2009
Surveillance of antituberculosis drug resistance among children from the Western Cape Province of South Africa--an upward trend.
Article in American journal of public health, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Drug-Resistant Tuberculosis Among Children: A Systematic Review and Meta-Analysis.Frontiers in public health · 2021Pooled it
- Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates.Lancet (London, England) · 2014Pooled it
- Intermittent versus daily therapy for treating tuberculosis in children.The Cochrane database of systematic reviews · 2014Pooled it
- Isoniazid-resistant tuberculosis in children: a systematic review.The Pediatric infectious disease journal · 2013Pooled it
- Moxifloxacin population pharmacokinetics and model-based comparison of efficacy between moxifloxacin and ofloxacin in African patients.Antimicrobial agents and chemotherapy · 2014Trial
- High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2012Trial
- Pulmonary tuberculosis case notification and burden of drug resistance among children under 15 years of age in Ethiopia: sub-analysis from third-round drug resistance tuberculosis survey.BMC pediatrics · 2023Article
- XDR-TB Transmitted from Mother to 10-Month-Old Infant: Diagnostic and Therapeutic Problems.Diagnostics (Basel, Switzerland) · 2022Article
- Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis in Children: The Role of Bedaquiline and Delamanid.Microorganisms · 2021Review
- Article
- Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach.Indian journal of pediatrics · 2019Review
- Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003).The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018Article
- Article
- Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children.BMC public health · 2018Article
- Treatment Outcomes of Children With HIV Infection and Drug-resistant TB in Three Provinces in South Africa, 2005-2008.The Pediatric infectious disease journal · 2017Article
- Drug-Resistant Tuberculosis among Children, China, 2006-2015.Emerging infectious diseases · 2017Article
- Drug resistance detection and mutation patterns of multidrug resistant tuberculosis strains from children in Delhi.Journal of epidemiology and global health · 2017Article
- Infectious Diseases of Poverty in Children: A Tale of Two Worlds.Pediatric clinics of North America · 2016Review
- Towards early inclusion of children in tuberculosis drugs trials: a consensus statement.The Lancet. Infectious diseases · 2015Review
- Childhood tuberculosis: a concern of the modern world.European respiratory review : an official journal of the European Respiratory Society · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe assessed the prevalence of antituberculosis drug resistance among children with tuberculosis (TB) in the Western Cape Province of South Africa.
methodsDrug susceptibility testing for isoniazid and rifampin was prospectively done on all children with culture-confirmed TB at Tygerberg Children's Hospital, Cape Town, from March 2005 through February 2007. Survey results were compared with results from 2 previous surveys.
resultsWe found 291 children had culture-confirmed TB. Resistance to isoniazid or rifampin increased from 21 of 306 (6.9%) to 41 of 319 (12.9%) and 43 of 285 (15.1%) in the first to third surveys (P = .005) and multidrug resistance from 7 of 306 (2.3%) to 18 of 319 (5.6%) and 19 of 285 (6.7%; P = .033). Although previously treated children had significantly more drug resistance than did new TB cases (19 of 66 [28.8%] vs 24 of 225 [10.7%]; odds ratio = 3.39; 95% confidence interval = 1.62, 7.05), evidence suggests transmission rather than acquisition of resistance. HIV infection was not significantly associated with drug resistance.
conclusionsResults indicate a high and rising prevalence of anti-TB drug resistance among children in the Western Cape, which suggests ongoing transmission of drug-resistant strains within the community. Improved control of TB in adults, including early identification and treatment of drug-resistant cases, is necessary to reduce transmission to children.
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