ArticleScience (New York, N.Y.)2009
Comment on "Human-specific gain of function in a developmental enhancer".
Article in Science (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Contrasts between adaptive coding and noncoding changes during human evolution.Proceedings of the National Academy of Sciences of the United States of America · 2010Pooled it
- GC-biased gene conversion drives accelerated evolution of ultraconserved elements in mammalian and avian genomes.Genome research · 2023Article
- Enhancer Function and Evolutionary Roles of Human Accelerated Regions.Annual review of genetics · 2022Review
- Accelerated Evolution of the Regulatory Sequences of Brain Development in the Human Genome.Molecules and cells · 2020Article
- Comprehensive identification and analysis of human accelerated regulatory DNA.Genome research · 2015Article
- Evolutionary dynamics of coding and non-coding transcriptomes.Nature reviews. Genetics · 2014Review
- Many human accelerated regions are developmental enhancers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- The footprint of metabolism in the organization of mammalian genomes.BMC genomics · 2012Article
- The role of GC-biased gene conversion in shaping the fastest evolving regions of the human genome.Molecular biology and evolution · 2012Article
- Evidence for widespread GC-biased gene conversion in eukaryotes.Genome biology and evolution · 2012Article
- Identification and characterization of lineage-specific highly conserved noncoding sequences in Mammalian genomes.Genome biology and evolution · 2012Article
- Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence.Nature reviews. Genetics · 2011Review
- Ongoing GC-biased evolution is widespread in the human genome and enriched near recombination hot spots.Genome biology and evolution · 2011Article
- Detecting positive selection within genomes: the problem of biased gene conversion.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- Surprising fitness consequences of GC-biased gene conversion: I. Mutation load and inbreeding depression.Genetics · 2010Article
- GC-biased evolution near human accelerated regions.PLoS genetics · 2010Article
- Scanning for the signatures of positive selection for human-specific insertions and deletions.Genome biology and evolution · 2009Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prabhakar et al. (Reports, 5 September 2008, p. 1346) argued that the conserved noncoding sequence HACNS1 has undergone positive selection and contributed to human adaptation. However, the pattern of substitution in HACNS1 is more consistent with the neutral process of biased gene conversion (BGC). The reported human-specific gain of function is likely due to the accumulation of deleterious mutations driven by BGC, not positive selection.
Indexed as
Identifiers
19197042What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.