Trial reportThe European respiratory journal2009
Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness.
Trial report in The European respiratory journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00021840 (Genetic Epidemiology of Asthma in Costa Rica), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Asthma in Costa Rica
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- The Asthma Risk Gene,Journal of respiratory biology and translational medicine · 2024Article
- VEGF and EGFR signaling pathways are involved in the baicalein attenuation of OVA-induced airway inflammation and airway remodeling in mice.Respiratory research · 2024Article
- Sex-specific alterations in the gut and lung microbiome of allergen-induced mice.Frontiers in allergy · 2024Article
- Review
- Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma.Allergy, asthma & immunology research · 2019Review
- Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- VEGFA GENE variation influences hallucinations and frontotemporal morphology in psychotic disorders: a B-SNIP study.Translational psychiatry · 2018Article
- The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD).Respiratory research · 2017Review
- Role of HIF1A, VEGFA and VEGFR2 SNPs in the Susceptibility and Progression of COPD in a Spanish Population.PloS one · 2016Article
- Increased Transcript Complexity in Genes Associated with Chronic Obstructive Pulmonary Disease.PloS one · 2015Article
- Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Genetic polymorphisms and risk of recurrent wheezing in pediatric age.BMC pulmonary medicine · 2014Article
- Vascular endothelial growth factor as a key inducer of angiogenesis in the asthmatic airways.Current allergy and asthma reports · 2013Review
- Article
- Association of variants in innate immune genes with asthma and eczema.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2012Article
- Asthma treatment outcome in children is associated with vascular endothelial growth factor A (VEGFA) polymorphisms.Molecular diagnosis & therapy · 2012Article
- Genetic variation in vascular endothelial growth factor-a and lung function.American journal of respiratory and critical care medicine · 2012Article
- Airway epithelial cells from asthmatic children differentially express proremodeling factors.The Journal of allergy and clinical immunology · 2012Article
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
- RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.American journal of respiratory and critical care medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
Vascular endothelial growth factor (VEGF) is an angiogenic factor implicated in asthma severity. The objective of the present study was to determine whether VEGF single nucleotide polymorphisms (SNPs) are associated with asthma, lung function and airway responsiveness. The present authors analysed 10 SNPs in 458 white families in the Childhood Asthma Management Program (CAMP). Tests of association with asthma, lung function and airway responsiveness were performed using PBAT software (Golden Helix, Inc. Bozeman, MT, USA; available at www.goldenhelix.com). Family and population-based, revpeated measures analysis of airflow obstruction were conducted. Replication studies were performed in 412 asthmatic children and their parents from Costa Rica. Associations with asthma, lung function and airway responsiveness were observed in both cohorts. SNP rs833058 was associated with asthma in both cohorts. This SNP was also associated with increased airway responsiveness in both populations. An association of rs4711750 and its haplotype with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC) ratio in both cohorts was observed. Longitudinal analysis in CAMP confirmed an association of rs4711750 with FEV(1)/FVC decline over approximately 4.5 yrs of observation. VEGF polymorphisms are associated with childhood asthma, lung function and airway responsiveness in two populations, suggesting that VEGF polymorphisms influence asthma susceptibility, airflow obstruction and airways responsiveness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.