Evidence map›Paper›PMID 19196648›Full record

ReviewPhysiology (Bethesda, Md.)2009

Novel mechanisms in the regulation of phosphorus homeostasis.

Theresa Berndt, Rajiv Kumar

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 2 syntheses or guidelines pooled it, 258 citations in OpenAlex.

  1. Pooled it
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  7. Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011
    Trial
  8. Article
  9. Phytase in Pig Diets: Technical and Economic Evaluation.Animals : an open access journal from MDPI · 2026
    Review
  10. On-slide Preparation ofbioRxiv : the preprint server for biology · 2026
    Article
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  20. bioRxiv : the preprint server for biology · 2024
    Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Theresa BerndtDepartment of Medicine, Nephrology Research, Mayo Clinic and Foundation, Rochester, Minnesota, USA. rkumar@mayo.edu
Rajiv Kumar
Mayo Clinic · US

Funding

REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7R01DK076829 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV · 2007 to 2010
$1.2M
Biology of a Novel Phosphaturic Protein - sFRP-4R01DK065830 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV · 2004 to 2007
$1.2M
NIDDK NIH HHS DK-076829NIDDK NIH HHS DK-65830NIDDK NIH HHS R01 DK065830NIDDK NIH HHS R01 DK076829
6 · The paper itself

Abstract

Phosphorus plays a critical role in diverse biological processes, and, therefore, the regulation of phosphorus balance and homeostasis are critical to the well being of the organism. Changes in environmental, dietary, and serum concentrations of inorganic phosphorus are detected by sensors that elicit changes in cellular function and alter the efficiency by which phosphorus is conserved. Short-term, post-cibal responses that occur independently of hormones previously thought to be important in phosphorus homeostasis may play a larger role than previously appreciated in the regulation of phosphorus homeostasis. Several hormones and regulatory factors such as the vitamin D endocrine system, parathyroid hormone, and the phosphatonins (FGF-23, sFRP-4, MEPE) among others, may play a role only in the long-term regulation of phosphorus homeostasis. In this review, we discuss how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus.

Indexed as

HomeostasisAnimalsFibroblast Growth Factor-23HumansIntestinal MucosaKidneyParathyroid HormonePhosphorusPhosphorus, DietaryTime FactorsVitamin DFGF23 protein, humanFibroblast Growth Factor-23Parathyroid HormonePhosphorusPhosphorus, DietaryVitamin D

Identifiers

PMID19196648
PMCPMC3963411
OpenAlexW2075425973

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.