ArticleParkinsonism & related disorders2009
Alpha-synuclein, alcohol use disorders, and Parkinson disease: a case-control study.
Article in Parkinsonism & related disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Alcohol consumption and risk for Parkinson's disease: a systematic review and meta-analysis.Journal of neurology · 2019Pooled it
- Role of the Gut-Brain Axis, Gut Microbial Composition, Diet, and Probiotic Intervention in Parkinson's Disease.Microorganisms · 2022Review
- Association Between Metabolic Syndrome and Mild Parkinsonian Signs Progression in the Elderly.Frontiers in aging neuroscience · 2021Article
- Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules.Biomolecules · 2020Review
- Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2020Review
- Alcohol Use Disorder, Neurodegeneration, Alzheimer's and Parkinson's Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity.Frontiers in cellular neuroscience · 2020Review
- Diet in Parkinson's Disease: Critical Role for the Microbiome.Frontiers in neurology · 2019Review
- Genetic Variants in SNCA and the Risk of Sporadic Parkinson's Disease and Clinical Outcomes: A Review.Parkinson's disease · 2017Review
- Alcohol Consumption and Parkinson's Disease Risk: A Review of Recent Findings.Journal of Parkinson's disease · 2015Review
- Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?Parkinsonism & related disorders · 2014Article
- Genetic susceptibility loci, environmental exposures, and Parkinson's disease: a case-control study of gene-environment interactions.Parkinsonism & related disorders · 2013Article
- A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.Synapse (New York, N.Y.) · 2013Article
- Epidemiology and etiology of Parkinson's disease: a review of the evidence.European journal of epidemiology · 2011Review
- Variants in estrogen-related genes and risk of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2011Article
- Common variants in PARK loci and related genes and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2011Article
- Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan.BMC neurology · 2010Article
- Estrogen-related and other disease diagnoses preceding Parkinson's disease.Clinical epidemiology · 2010Article
- Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.Human molecular genetics · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Collaborative pooled analyses demonstrated that allele length variability of the dinucleotide repeat sequence within the alpha-synuclein gene promoter (SNCA REP1) is associated with Parkinson disease (PD) worldwide. Other studies demonstrated that variability in the SNCA promoter is also associated with alcohol use disorders, but not consistently. Yet other studies demonstrated that alcohol use disorders are inversely associated with PD, but not consistently. The aim of this study was to clarify the patterns of association between REP1 genotype, alcohol use disorders, and PD. Cases were recruited from the Department of Neurology of the Mayo Clinic in Rochester, MN. The controls included unaffected siblings and unrelated controls. We assessed alcohol use via a structured telephone interview and screened for alcohol use disorders using the CAGE questionnaire. REP1 genotyping was performed using an ABI 3730XL platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined using conditional logistic regression models. We recruited 893 case-control pairs. There was an increasing risk of PD with increasing SNCA REP1 allele length (OR 1.18 for each REP1 genotype score unit, 95% CI 1.02-1.35; p=0.02). There was a decreasing risk of PD with increasing CAGE score (p=0.01). The association of REP1 score with PD remained significant after adjusting for CAGE score, and the association of CAGE score with PD remained significant after adjusting for REP1 score. There were no pairwise interactions. Our findings suggest that SNCA REP1 genotype and alcohol use disorders are independently associated with PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.