ArticleBMC psychiatry2009
Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder.
Article in BMC psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Presence of recombination hotspots throughout SLC6A3.PloS one · 2019Trial
- The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models.Frontiers in psychiatry · 2024Review
- Functional SLC6A3 polymorphisms differentially affect autism spectrum disorder severity: a study on Indian subjects.Metabolic brain disease · 2022Article
- Study of changes in rs2283265 polymorphisms in dopamine receptor D2 and rs27072 in dopamine transporter gene (SLC6A3) in patients with attention-deficit hyperactivity disorder.Iranian journal of child neurology · 2022Article
- The influence of genetic variants on striatal dopamine transporter and D2 receptor binding after TBI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Advances in molecular genetic studies of attention deficit hyperactivity disorder in China.Shanghai archives of psychiatry · 2014Review
- Human dopamine transporter gene: differential regulation of 18-kb haplotypes.Pharmacogenomics · 2013Article
- Association of dopamine transporter gene variants with childhood ADHD features in bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Sleep disturbances in children with attention-deficit/hyperactivity disorder.Expert review of neurotherapeutics · 2011Review
- Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.Journal of child psychology and psychiatry, and allied disciplines · 2011Review
- Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity.Behavioural brain research · 2010Article
- Molecular genetics of attention-deficit/hyperactivity disorder: an overview.European child & adolescent psychiatry · 2010Review
- Response to methylphenidate is not influenced by DAT1 polymorphisms in a sample of Brazilian adult patients with ADHD.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Brain plasticity and genetic factors.Topics in stroke rehabilitationReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAttention deficit hyperactivity disorder (ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/SLC6A3) has been considered a good candidate for ADHD. Most association studies with ADHD have investigated the 40-base-pair variable number of tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1. Only few studies have reported association between promoter polymorphisms of the gene and ADHD.
methodsTo investigate the association between the polymorphisms -67A/T (rs2975226) and -839C/T (rs2652511) in promoter region of DAT1 in ADHD, two samples of ADHD patients from the UK (n = 197) and Taiwan (n = 212) were genotyped, and analysed using within-family transmission disequilibrium test (TDT).
resultsA significant association was found between the T allele of promoter polymorphism -67A/T and ADHD in the Taiwanese population (P = 0.001). There was also evidence of preferential transmission of the T allele of -67A/T polymorphism in combined samples from the UK and Taiwan (P = 0.003). No association was detected between the -839C/T polymorphism and ADHD in either of the two populations.
conclusionThe finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.